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immunosuppressant drug monitoring: research supports microsampling

Posted by Neoteryx on Jan 14, 2020 4:43:00 AM

Therapeutic drug monitoring (TDM) for immunosuppressive drugs (ISPs) is a critical component of post-tissue and organ transplantation therapy. This is because ISP drugs have high intra- and inter-subject variability and a narrow therapeutic window. Initially, quantitative analyses of ISPs such as sirolimus, cyclosporine A, tacrolimus, and everolimus used whole blood specimens.

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Topics: Alternative to Dried Blood Spot, Alternative to Venipuncture, Immunosuppressants

therapeutic drug monitoring of immunosuppressants: an overview

Posted by Neoteryx on Jan 6, 2020 2:52:00 AM

When administering immunosuppressants, clinicians need to individualize a patient’s drug therapy. The goal is to attain an optimal balance between therapeutic efficacy and the probability of adverse effects. Patients present varying pharmacodynamics and pharmacokinetics, so achieving this goal can be challenging.

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Topics: Alternative to Dried Blood Spot, Alternative to Venipuncture, Immunosuppressants

microsampling in pharmaceutical drug discovery and development: the patient-centric approach

Posted by Neoteryx on Dec 9, 2019 4:46:00 AM

Patient-centric healthcare has taken center-stage. With the increasing access to information, patients want to play a role in treatment methods and applications. Patient-centric sampling has an important part to play.

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Topics: Clinical Trials, Alternative to Dried Blood Spot, Alternative to Venipuncture, Remote Patient Monitoring

5 considerations for the application of microsampling in drug discovery

Posted by Neoteryx on Nov 26, 2019 12:34:00 AM

Data collected in vivo is mandatory to make informed decisions about drug development and screening. Researchers previously relied on animal models to obtain experimental measurements. The collection of specimens was invasive, labor-intensive, time-consuming, and costly.

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Topics: Alternative to Dried Blood Spot, Animal Testing, Alternative to Venipuncture

the dried blood sampling landscape: Michele Protti, PhD, on microsampling

Posted by Neoteryx on Nov 14, 2019 4:30:00 AM

At Neoteryx, we work with top scientists and researchers to help facilitate and promote their revolutionary work using Mitra® microsampling devices and Volumetric Absorptive Microsampling (VAMS®) technology.

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Topics: Alternative to Venipuncture, Remote Patient Monitoring

microsampling in proteomics: mass spec, multiplexed protein biomarkers, and improving patient outcomes

Posted by Neoteryx on Nov 6, 2019 5:45:00 AM

New work using microsampling in proteomics has transformative implications for science and research, for patient outcomes, and for the way labs do business.

"Having spent years attempting to discover new protein biomarkers, the most interesting and highly motivating thing about our proteomics work is how we might now be able to bring it to the stage where it has impact by improving patient outcomes," says Dr. Stephen Pennington of University College Dublin, whose work in proteomics using Mitra® microsampling devices has indeed begun to garner wider attention.

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Topics: Alternative to Dried Blood Spot, Alternative to Venipuncture, Remote Patient Monitoring