Expert interpretation of drug concentration is critical to understanding pharmacokinetics and realizing full its clinical benefits. Clinicians achieve this by monitoring drug pharmacodynamics routinely and measuring physiological indices of therapeutic responses directly. However, the vast inter-individual variation between drug response and dosages makes it challenging to individualize drug dosage.
Immunosuppression prevents and treats acute rejection and graft damage during kidney transplantation. The development immunosuppressive agents such as tacrolimus, cyclosporine, and mycophenolate minimized the rejection rate and improved short-term graft survival.
Over the past five decades, the medical community has witnessed considerable advancements in organ transplants. Patients receive organs, and through immunosuppressive drugs, their bodies can accept the organ.
When Fasha Mahjoor launched Neoteryx, he planned to change the way dried capillary blood is collected, to become the most significant blood microsampling innovator in the modern marketplace. In that, he and his team have surely succeeded.
Topics: Clinical Diagnostics, Clinical Trials, Alternative to Dried Blood Spot, Animal Testing, Pediatrics, RNA / DNA from Dried Blood, Capillary Blood Sampling, Vet Diagnostics, Alternative to Venipuncture, Remote Patient Monitoring, Health and Wellness, Immunosuppressants
When using immunosuppressant drugs as an organ transplant recipient, it is crucial to effectively and consistently monitor drug levels. This requires therapeutic drug monitoring and an understanding of requirements and best practices for therapeutic drug monitoring in the laboratory.
Therapeutic drug monitoring (TDM) for immunosuppressive drugs (ISPs) is a critical component of post-tissue and organ transplantation therapy. This is because ISP drugs have high intra- and inter-subject variability and a narrow therapeutic window. Initially, quantitative analyses of ISPs such as sirolimus, cyclosporine A, tacrolimus, and everolimus used whole blood specimens.