This thinking was the impetus for the 3Rs – Replace, Reduce, and Refine – a global movement to improve our systems of animal research. By properly implementing the 3Rs, preclinical labs can produce better results and research while causing less stress and suffering to rodents and other experimental animals.
This occurs because microsampling allows the same animals to be sampled at a range of time points. It also cuts reliance on satellite populations. For lab rodents, rat tail blood collection can reduce stress and prolong life. And it gives rise to better circumstances for their human coworkers, as well.