During the development process of a new drug, it is crucial to get accurate results on how the drug reacts on the individuals on which it is being tested. Procedures such as drug metabolism (DM) and pharmacokinetic (PK) studies require blood draws. Before the 1960s, the primary method was drawing large volumes of blood using the traditional method (venipuncture). However, with the emergence of dried blood spot (DBS) technique, only a small amount of blood is required in many cases.
Topics: Dried Blood Spot Sampling
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Topics: Clinical Research, Clinical Trials, Dried Blood Spot Sampling, RNA / DNA from Dried Blood, Remote / Home Blood Collection, Blood Sample Transport / Storage, Smarter Healthcare, Patient Monitoring
Capillary finger-prick blood draws have gained popularity. This is partly in response to innovations in point of care testing and remote sampling. Capillary blood has distinct advantages in hospital labs, clinical labs, and in other circumstances requiring on-site sampling and other more traditional blood collection practices. An ongoing quest to streamline workflows and make them more efficient has led to a reconsideration of dried blood spot sampling.
Working with traditional wet blood specimens has always raised safety concerns and posed logistical challenges. Blood sample storage and cold chain shipping require navigating an increasingly complicated maze of regulatory issues. It's no wonder that dried blood spotting has emerged in the last few decades as a preferable alternative in many cases.
Scientists and researchers from the Swiss Tropical and Public Health Institute recently provided new, strong evidence for the efficacy of pediatric pharmacokinetic (PK) studies using Mitra® devices. They tested Mitra technology against standard-issue DBS cards, within the framework of a randomized controlled trial, on 35 school-aged children in rural Côte d’Ivoire infected with Schistosoma haematobium.