New work using microsampling in proteomics has transformative implications for science and research, for patient outcomes, and for the way labs do business.
"Having spent years attempting to discover new protein biomarkers, the most interesting and highly motivating thing about our proteomics work is how we might now be able to bring it to the stage where it has impact by improving patient outcomes," says Dr. Stephen Pennington of University College Dublin, whose work in proteomics using Mitra® microsampling devices has indeed begun to garner wider attention.
During the development process of a new drug, it is crucial to get accurate results on how the drug reacts on the individuals on which it is being tested. Procedures such as drug metabolism (DM) and pharmacokinetic (PK) studies require blood draws. Before the 1960s, the primary method was drawing large volumes of blood using the traditional method (venipuncture). However, with the emergence of dried blood spot (DBS) technique, only a small amount of blood is required in many cases.
Topics: Alternative to Dried Blood Spot
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Capillary finger-prick blood draws have gained popularity. This is partly in response to innovations in point of care testing and remote sampling. Capillary blood has distinct advantages in hospital labs, clinical labs, and in other circumstances requiring on-site sampling and other more traditional blood collection practices. An ongoing quest to streamline workflows and make them more efficient has led to a reconsideration of dried blood spot sampling.
Working with traditional wet blood specimens has always raised safety concerns and posed logistical challenges. Blood sample storage and cold chain shipping require navigating an increasingly complicated maze of regulatory issues. It's no wonder that dried blood spotting has emerged in the last few decades as a preferable alternative in many cases.