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the microsampling blog

The Critical Role of Dose Calculation in Immunosuppressant Therapy (IST)


It's a familiar situational irony that many life-saving medications and courses of treatment used in modern medicine double as potentially lethal poisons.  While they can bring profound healing and relief, when misused, they can be dangerous, even lethal. This duality is heightened in treatments like vaccines, chemotherapy, and especially in organ transplantation, which introduces a foreign entity into the human body.
In transplantation, the organ itself is the “treatment” of the patient’s ailment, but transplanting a donor organ into a recipient is the equivalent of planting a ticking time-bomb in their body. Even in cases of a close match, the body’s immune response mounts an attack against the foreign organ, causing graft loss and rendering the organ useless.

The Delicate Balancing Act

the-critical-role-dose-calculation-immunosuppresentsIn organ transplantation Immunosuppressant Therapy (IST) is a crucial player. While it's a necessity to prevent the body's rejection of the new organ, the therapy itself can introduce new risks. By suppressing the immune response, these medications also lower the body's defenses against other potential infections.

Determining the correct dosage of IST is vital. An overdose can make a patient vulnerable to infections, while an underdose can cause the body to reject the new organ. For that reason, it is of paramount importance to get the right combination of immunosuppressive drugs and to calibrate the dosage exactly in order for the “poison” to stay within its narrow therapeutic window. It's a thin tightrope that medical professionals must walk, requiring precision and frequent monitoring.

One Size Does Not Fit All

individual-react-differently-to-medications-race-age-medical-historyThe challenge is that every individual reacts differently to medications. Factors such as race, age, and medical history come into play. As a result, the era of "one size fits all" medication has ended. Today's approach focuses on the individual, understanding their specific needs, and continuously adjusting the treatment based on feedback. This feedback loop is maintained using Therapeutic Drug Monitoring (TDM).

Given the delicate individual balance that must be struck and the devastating consequences if immunosuppressant levels are wrong, it is shocking that the biggest problem with IST isn’t actually the calibration of medication by the practitioner, but rather the non-adherence of patients to their post-op regimens.

A shocking number of patients miss their doses, making it all the more difficult for doctors to remain informed about their patients’ status and to make changes accordingly.

Innovation for Better Monitoring: Blood Microsampling

Mitra 2-Sampler Cartridge and Collection Kit-2

One solution gaining traction is blood microsampling. This technique allows patients to draw a small blood sample via a simple finger prick at home, which they can then send to a lab for analysis. This cuts out time spent traveling to and from the clinic and eliminates the need for painful blood draws where large volume samples are taken. At-home sampling offers doctors more frequent data, enabling them to better calibrate the patient’s IST regimen

The Way Forward

With organ transplantation, there's no margin for error. The stakes are high, with patients' lives hanging in the balance. But with technological advances and new methods like blood microsampling, we're moving towards a world where treatment is not only more effective but also more personalized and patient-centric.

As healthcare evolves, our approach to treatment and monitoring must evolve as well, prioritizing the comfort and convenience of the patient while ensuring the highest quality of care. The introduction of innovative techniques like blood microsampling is a significant step in that direction.

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