One of the most exciting presentations on microsampling in 2018 came from Jeff Plomley, Manager and Principal Scientist supporting Bioanalytical Innovator and Pre-clinical programs at Quebec-based Altasciences.
Impact-Assisted Extraction: A Novel Sample Preparation Workflow
Next, the presentation goes into detail on the process of Impact-Assisted Extraction. Through the course of this process, tips remain intact, with free rotation in the bottom of the well plate, thereby aiding in the achievement of high extraction efficiencies.
Plomley walks through the workflow and explains the process - not just the "how," but the "why" as well.
Better Drug Monitoring Through Microsampling
After explaining the sophisticated extraction methodology, Plomley presents Altasciences’ work in evaluating the efficacy of dried capillary blood microsampling technology for the determination of Naproxen, Exenatide, and Rituximab in support of preclinical investigations.
VAMS, he concludes, has key advantages in this area, as it supports a fast and effective direct-extraction workflow methodology. Furthermore, “Long-term stability assessments and ISR data from clinical studies suggests reproduceable extractability regardless of sample age,” Plomley says.
The Future of VAMS, the Future of Blood Collection
Further investigation, he suggests, will include exploring the demonstrated promise of bottom-up quantitation using "in-tip" digestion and the application of Mitra in the much-anticipated area of painless methods of blood collection.
Plomley and the Altasciences team have once again performed essential work in the development and road-testing of VAMS as the blood-collection breakthrough we've always known it to be.
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