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In the US, use of the Mitra device with blood is limited to research and non-diagnostic applications. In many countries outside the US, the Mitra device is approved as a remote blood sample collection device for some clinical applications, as referenced in some content.

capillary blood collection: advantages and disadvantages

by Neoteryx | 2 min read

Collecting a micro sample of capillary blood from the heel of an infant

Capillary blood collection has been around for decades. When it began, the technique was used to obtain blood from infants for genetic screening. Drawing five or ten µl from a newborn can be difficult and potentially harmful, so small-volume sampling had obvious applications in this area.

Capillary blood is obtained by pricking a finger in adults and a heel in infants and small children. The specimen is then collected with a pipette, placed on a glass slide or a piece of filter paper, or is absorbed by the tip of a microsampling device. Capillary blood is used for glucose measurements by transferring the blood to a test strip.

Differences in Results

The differences between capillary blood versus plasma in most cases are minimal. However, there are some discrepancies in hemoglobin and hematocrit values and in platelet counts. Glucose levels also have a small disparity. Venous blood glucose is generally slightly higher than capillary blood glucose measured at the same time. These laboratory reports need to be evaluated in light of the sampling method used.


Advantages of Capillary Blood Collection
at home blood collection with the mitra cartridge blood specimen device

  • Only a very small amount of blood is needed. ICU patients can lose up to two percent of their total blood volume every day when venous blood sampling is done.
  • Collection is simple and relatively painless. Finding a vein in an elderly patient or a child can be a nightmare and traumatic for both the lab tech and the patient.
  • Patients can be taught to do capillary blood collections at home. Diabetics routinely check their blood sugars this way.
  • Collection sites can be changed so that the risk of scarring and pain is lessened.
  • Increasing adoption and implementation in hospital labs and patient-centric clinical testing and clinical research labs


Disadvantages of Capillary Blood Collection

  • Not all tests can be run on capillary samples.
  • Capillary blood collection can sometimes rupture the blood cells, producing results that are inaccurate.
  • Problems with bleeding and infection can occur with either method.
  • Patients may feel faint after any type of blood drawing.
  • Overuse of the same area for collection can cause scarring.
  • Calcified nodules can develop at the site of collection, especially in infants. The nodules usually resolve by themselves.

In general, capillary blood collection is much preferred by both patients and lab technicians. The method is simpler, less painful, and rarely requires a "second stick." Results are comparable between capillary blood versus plasma except in a few cases. In those cases, the results need to be correlated with data from the same collecting method.

Originally published Jul 13, 2017 7:27:00 AM, updated on September 15, 2020