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the microsampling blog

capillary blood collection: a journey through history

The intricacies of our circulatory system have long fascinated medical practitioners and researchers. Capillaries - the tiny blood vessels connecting arteries and veins - play an essential role within this system. When the finger's tip is pricked, the blood emerging is sourced from these capillaries, marking the essence of capillary blood sampling.

The Ancient Practice of Bloodletting

ancient surgical tools, from the 5th century BC, GreeceDating back to the time of Hippocrates in the 5th century BC, blood extraction has held significance in medical practice. For centuries, bloodletting, considered a "heroic treatment," was employed to purge "bad humors" believed to be the culprits behind illnesses. This therapy, though intended to be life-saving, often proved detrimental. Leeches were commonly used, indicating the rudimentary nature of early blood sampling.

Discovery of the Circulatory System

microscopic view of blood cellsSir William Harvey, an English physician in the early 17th century, provided a groundbreaking revelation by identifying the circulatory system. Interestingly, capillaries, the critical bridges between arteries and veins, weren't discovered during his lifetime.

Transition to Diagnostic Blood Sampling

19th-century-blood-diagnostic-examinationBy the late 19th century, the focus shifted from therapeutic blood drawing to diagnostic examination. Bloodletting, with its historical significance, gradually vanished as the scientific community began to understand blood's vast diagnostic potential. In the subsequent years, blood became the epicenter of numerous studies, revealing the functions of countless proteins, lipids, and carbohydrates. Advanced microscopic and submicroscopic evaluations of blood cells have since paved the way for treating numerous diseases.

The Advent of Venipuncture and its Limitations

venipuncture-alternative-capillary-samplingThe traditional method of obtaining blood, venipuncture, involves drawing 5 to 10 ml of blood by piercing a vein with a needle. Although effective, this method posed a risk. In cases where numerous tests were ordered, patients could develop anemia due to excessive blood extraction.

Revolutionizing Blood Sampling: Dr. Robert Guthrie's Contribution

DBS Card1962 marked a transformative year in blood sampling. Dr. Robert Guthrie modified the test for phenylketonuria, a congenital disease. Early detection post-birth and prompt treatment could prevent the impending mental retardation associated with the disease. The challenge, however, was extracting blood from every newborn. Dr. Guthrie ingeniously developed a test requiring just a drop of dried blood on filter paper, obtainable by a single prick on the baby's heel.

The Modern Era of Capillary Blood Sampling

Product post 12_7With today's technological advancements, we can conduct hundreds of tests using just a single drop of blood. The days of painful vein searches and the associated risks of iatrogenic anemia are behind us. Capillary blood sampling, which is less painful, has revolutionized patient-centric care. The ability for patients to self-sample eliminates the need for a professional, thus reducing costs. As home-based testing becomes more common, prioritizing patient convenience defines modern medical practice. We've come a long way from leeches.

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