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the microsampling blog

exploring alternatives to scalpel and traditional punch skin biopsies

Side by Side photos. On the right a typical wound from a traditonal skin biopsy and on the left a micro sized wound from a Microbiopsy punch

In recent times, advancements in analytical instrumentations such as Hyphenated Mass Spectrometry (LC-MS, GC-MS, etc.), PCR technologies, and others have provided the opportunity for microsampling collection techniques to arise. The demand for less invasive methods of collecting biological samples has finally arrived for dermatology with the novel development of the Harpera™ Microbiopsy™ Punch.

Traditional skin biopsies, which often entail invasive and painful surgical procedures, are being reconsidered as many discover and explore the newer Microbiopsy, which is a smaller, less invasive punch alternative. Unlike conventional methods with their stitches and scarring, Harpera's spring-loaded microsampling technology offers a quick, precise and virtually painless skin sampling event, providing a significant relief from the discomfort patients usually experience.  

The Harpera Microbiopsy Punch presents a more straightforward skin sampling procedure that may reduce the risk of infection or complications and accelerate recovery time—while offering a gentler alternative to traditional skin sampling procedures. This signals to the community the arrival of a technological advancement that can improve the patient experience and research outcomes in ways that have not been possible before.

The table below summarizes the key advantages of skin Microbiopsy punch over the traditional biopsy punch method to collect a skin specimen.

 

Traditional Biopsy Punch 
a traditional biopsy punch tool

Harpera™ Microbiopsy™ Punch 
the harpera microbiopsy punch device

scalpel knife
Invasiveness 

Requires cutting a 3-6mm piece of skin tissue 

Collects a micro specimen, with a small puncture (0.1 x 0.5mm)  

a clock
Procedure Time
 

Takes about 15-30 minutes 

Takes few seconds 

a nerve radiates a frequency symbol depicting the sensation of pain.
Pain Level
 

Typically requires local anesthesia 

Does not require anesthesia 

Two bandages
Wound Care 

Requires stitches and/or wound dressing 

No stitches, minimal wound. No scar 

the universal plus sign medical symbol in a circular arrow.
Recovery 

Recovery time can be several days to weeks, depending on the biopsy site 

Faster healing, typically within a few days 

a hand palms the money symbol
Cost 

Physician and nurses required to perform procedure. 

30 USD of materials.  

80 USD for whole procedure1  

Any healthcare provider (i.e. nurse) can perform procedure.  

20 USD in materials. 

Est. 30 USD for whole procedure 

arrows going around in circles
Frequency 

Not suited for multiple biopsies in narrow time window 

Suited for frequent sampling at one site and/or over time 

 

Third-party Publications:

See the complete publications list here

shifting toward minimally invasive skin biopsies 

Harpera's non-invasive technology can be the ideal sampling device to be used in conjunction with a wide range of dermatological applications, from diagnosing skin cancers to monitoring chronic skin conditions. Its ability to perform fast, easily repeatable sampling procedures without significant discomfort or damage to the skin makes it particularly valuable in studies requiring longitudinal monitoring.

Microbiopsy technology allows for continuous assessment with minimal impact on the patient's quality of life. Embracing this technology may positively impact the future of dermatological sample collection and rewrite the patient experience. It has the potential to offer a future where skin biopsies become quick, painless, and more accessible than ever.

1 Matsumoto, M., et al. (2018). “Estimating the cost of skin cancer detection by dermatology providers in a large health care system.” J Am Acad Dermatol 78(4): 701-709 e701.

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