Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This presentation examines volumetric absorptive microsampling in biomarker analysis, with a focus on insights from targeted and untargeted metabolomics approaches. 1) VAMS (Mitra) has the capability to provide accurate and precise quantification of certain amino acids and biogenic amines in dried capillary blood compared to blood and plasma.
This presentation outlines optimization of rapid microbore metabolic profiling for blood microsamples. It evaluates whether the approach can identify biomarkers that distinguish microsamples from conventional venous blood and plasma matrices.
This presentation examines nanoparticle enrichment of volumetrically accurate microsampled blood for enhanced proteomic analysis of dried blood.
This thesis examines antibody response to SARS-CoV-2 vaccine in transplant recipients and hemodialysis patients from the Dominican Republic. The CO group showed a rapid, early peak in anti-S and anti-RBD IgG levels, followed by stabilization.
This thesis examines advancing therapeutic drug monitoring of CYP3A4-metabolized drugs, with a focus on analytical innovations and clinical applications. Altogether, the study demonstrates that the combined use of TRR, C/D ratio, DRC, and MR may support routine practice by facilitating the detection of non-adherence, drug interactions, and patient subgroups whose pharmacokinetics deviate from the expected cohort, thereby enabling the potential for individualized dose adjustments.
This study examines volumetric absorptive microsampling for profiling of signaling lipids, with a focus on a comparative analysis with whole blood and dried blood spots. These findings provide initial evidence supporting VAMS as a feasible and promising alternative to DBS for signaling lipid profiling.
This study examines volumetric absorptive microsampling during spaceflight for analysis of acetaminophen pharmacokinetics in whole blood. C(max), AUC, V(z)/F, and CL/F showed residual changes 3 days post-flight (R + 3).
This study examines volumetric absorptive microsampling device for forensic toxicologic screening, with a focus on a case report as proof-of-concept. These results indicate that Mitra-based microsampling can support qualitative toxicological screening and non-targeted analysis in post-mortem investigations when sample volumes are limited.
This study examines volumetric absorptive microsampling (VAMS) for therapeutic drug monitoring of antiseizure medications (ASMs) in pediatric patients. Comparison of estimated vs. observed plasma results showed a successful predictive performance for this conversion approach.
This study validated a liquid-liquid extraction and LC-MS/MS method for cannabinoid quantitation using 50 µL of liquid whole blood. The microsampling-compatible method achieved sub-ng/mL sensitivity and may support roadside capillary collection when conventional venipuncture is impractical.
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