Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Purpose – Develop the method based on dried plasma spots (DPS) obtained by a micro‐sampling device to quantify rigosertib in mouse and human plasma using LC/MS/MS.
This presentation examines advantages and limitations of microsampling, hematocrit and MicroLC in DBS, with a focus on quantitative bioanalytical assays for immunosuppressants, warfarin and methylphenidate in whole blood.
This study compares VAMS technology with traditional dried-blood-spot sampling for a ligand-binding assay. VAMS reduced hematocrit-related effects and supported accurate, precise measurements across the evaluated storage conditions.
This study compares conventional vs. microsampling methodologies for in vivo pharmacokinetic studies in rodents. The precise and hematocritindependent transfer of 10 μL whole blood from the blood retrieval sites evaluated (cardiac puncture and saphenous vein) make it possible to conduct full pharmacokinetic time-course profiles in a small number of animals, supporting the ethical use of rodents in research and development.
This study evaluated Mitra microsampling for acetaminophen pharmacokinetic studies in rats. The workflow supported serial whole-blood sampling, reduced animal use, and produced pharmacokinetic results consistent with published data.
This thesis describes the design, manufacture, and evaluation of a minimally invasive skin microbiopsy for molecular research. It reports sample yields, volunteer testing, targeted lesion sampling, and downstream molecular applications while identifying low-input analytical variability as an area for further work.
Dermoscopy-targeted microbiopsy and sequencing were used to examine genetic heterogeneity within a melanoma in situ arising in a dysplastic nevus. The melanoma component was BRAF wild type, while the nevus contained both wild-type and BRAF V600E results, demonstrating spatially targeted molecular sampling.
Researchers validated a VAMS method for paracetamol measurement and used it in a rat toxicokinetic study. The method produced parameters comparable with conventional samples and simplified collection and analysis, although controlling blood flow was important to prevent overfilling the sampler.
This study developed an LC-MS method for intact TAT-fusion therapeutics in biological samples. The workflow improved sensitivity and successfully quantified a model TAT-conjugated therapeutic in rat plasma.
This cross-laboratory study evaluated a volumetric dried-blood sampler across a broad hematocrit range. Collected volume remained consistent between laboratories, supporting the device’s potential to overcome common DBS volume and hematocrit limitations.
Microsampling and Microbiopsy specialists are available to provide expert support for the success of your project.
