Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This thesis develops a cannabinoid LC-MS/MS assay using VAMS and compares two extraction approaches. Stability and precision limitations prevented full M10-compliant validation. The findings support further method development, including evaluation of inline extraction.
This study validates an HPLC-MS/MS method for nine cannabinoids and metabolites in hemaPEN-collected dried blood. Separate extraction protocols accommodate different sensitivity requirements, and the method was applied to authentic blood specimens.
This review examines microsampling for chemical threat agents, toxins and potent synthetic opioids in biological matrices. It covers VAMS and dried blood spot approaches, analytical methods and logistical advantages, while identifying stability and standardization challenges.
This review examines microsampling for oligonucleotide and biologic bioanalysis, including VAMS, dried blood spots and capillary approaches. It discusses collection burden, matrix bias, recovery, stability and sensitivity, along with extraction and analytical methods needed for reliable implementation.
This poster adapts a Roche Cobas i601 immunosuppressant assay to 10 µL Mitra VAMS samples. Tacrolimus met the stated performance criteria, while other analytes required further optimization. Paired patient and venous whole-blood samples are proposed as the next evaluation step.
Across four clinical studies, this poster compares sample adequacy with Mitra, Telimmune and hemaPEN devices. Staff-collected samples had generally higher adequacy than patient-collected hemaPEN samples; staff experience, required volume and collection frequency also affected success.
This poster adapts a plasma metanephrine assay to 30 µL Mitra-collected blood. Results support measurement of metanephrine and normetanephrine, while 3-methoxytyramine remains affected by whole-blood response, calibration and sensitivity limitations that require further optimization.
This poster develops an LC-MS/MS method for total reducible D-penicillamine in Mitra VAMS, whole blood and plasma. It investigates sample stabilization and relationships between matrices to support low-volume monitoring in patients with Wilson’s disease.
This poster develops automated TPMT activity profiling from dried Mitra VAMS samples. Analytical validation and proof-of-concept comparisons with liquid whole blood support simplified phenotyping, with activity retained during refrigerated storage.
This poster evaluates LC-MS/MS measurement of thiopurine metabolites using VAMS, quantitative dried blood spots and conventional erythrocyte samples in pediatric transplant recipients. The microsampling methods showed promising analytical performance and agreement, while larger studies are needed to establish clinical interchangeability.
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