Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This study applies an automated microsampling technique to trazodone and paracetamol. The obtained results confirm the suitability of VAMS for non-clinical PK studies and its advantages towards the implementation of 3Rs strategy.
This presentation compares a ten-point pharmacokinetic profile collected from a single mouse using Mitra microsampling with conventional plasma sampling. The two approaches produced similar pharmacokinetic profiles and parameter estimates.
This study compared conventional plasma sampling with serial Mitra dried-blood microsampling in mouse acetaminophen pharmacokinetic studies. Mitra enabled complete time-course profiles with fewer animals and supported potential integration of PK, pharmacodynamic, and efficacy assessments.
This technical brief provides common extraction protocols for dried blood collected with 10 or 20 µL Mitra microsamplers. The protocols are based on analyte LogP and typically achieve extraction recoveries of 80% or greater.
This technical brief presents a high-throughput protein-precipitation method for extracting clinically important pain-panel drugs from dried blood collected with Mitra devices for LC-MS analysis.
This technical brief describes two approaches for preparing calibration standards and quality controls with Mitra devices. It compares serial dilution in blood with equivalent-volume solvent spiking and explains the practical tradeoffs.
This study compared Mitra microsampling with conventional wet-blood methods for monitoring immunosuppressants in transplant patients. Strong correlations for cyclosporin A supported the potential use of convenient at-home microsampling in therapeutic drug monitoring.
This technical brief evaluates two extraction procedures for measuring clinically important hormones and steroids from dried blood collected with Mitra devices by LC-MS/MS. The workflows use either methanol extraction or high-throughput protein precipitation.
This study evaluated total RNA and DNA purification from blood collected with Mitra VAMS devices. The resulting nucleic acids were successfully used in downstream applications including qPCR, Sanger sequencing, and next-generation sequencing.
This study evaluated skin microbiopsy for collecting cells from cutaneous warts and surrounding skin. The samples were used to detect the spatial presence of human papillomavirus DNA with a minimally invasive, targeted approach.
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