Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Researchers developed an RPLC- and HILIC-MS workflow for non-targeted metabolomics using DBS and VAMS blood microsamples. The optimized extraction and chromatography methods expanded detection across polar and non-polar metabolite classes.
Researchers validated an ICH M10-compliant LC-MS/MS method for creatinine in plasma, dried plasma spots, and VAMS. Dried plasma spots produced plasma-equivalent measurements directly, while VAMS required regression-based correction and remained stable for up to three months.
This clinical study evaluated DBS and VAMS for venetoclax monitoring in patients with leukemia. Hematocrit-based correction produced strong agreement with plasma, and most participants could self-collect usable samples at home, with higher usability ratings for VAMS than DBS.
This clinical study evaluated volumetric absorptive oral-fluid microsampling as an alternative to urine testing in substance-use-disorder care. Paired testing showed high agreement for most analytes and improved patient acceptability, while matrix-specific detection windows and turnaround times remained limitations.
This study validated LC-MS/MS measurement of methotrexate polyglutamates across conventional blood matrices, DBS, and VAMS in rheumatoid arthritis. VAMS and DBS produced closely comparable capillary-sample results, although matrix-specific differences must be considered when relating them to red-blood-cell measurements.
Researchers validated LC-MS/MS measurement of three adrenal steroids in plasma, blood, and 20 µL VAMS samples for congenital adrenal hyperplasia monitoring. VAMS performance was accurate and precise across hematocrit and storage conditions, supporting future home-based monitoring.
This review evaluates chromatographic and mass-spectrometric methods using DBS and VAMS for sports drug monitoring. It summarizes analytical applications and highlights remaining barriers involving detection windows, device comparability, sample preparation, stability, and regulatory acceptance.
Researchers validated UPLC-MS/MS measurement of linezolid and its metabolites in oral fluid and capillary blood collected by VAMS. Linezolid correlated strongly with plasma in both matrices, while metabolite monitoring still requires matrix-specific correction and further clinical validation.
This application note discusses VAMS for therapeutic drug monitoring of tamoxifen metabolites, including N-desmethyltamoxifen and endoxifen. It highlights small-volume collection, room-temperature stability, and reduced dependence on conventional plasma sampling.
This user guide summarizes best practices for research using Mitra devices with VAMS technology. It covers initial method-development decisions, dried-matrix handling, ambient shipping, storage, and sample collection.
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