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Microsampling Publications Library

Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.  

Search results are matched to the publication record, including title, abstract, keywords, authors, and other indexed details. All search terms must appear in the record for it to be included in your results.

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Bioanalysis of six antibiotics from volumetric microsamples: a new tool for precision dosing in critically ill children

Takyi-Williams, J.; Leino, A. D.; Li, R.; Downes, K. J.; Zuppa, A. F.; Bwint, A.; Wen, B.; Sun, D.; Scheetz, M. H.; Pai, M. P.
Bioanalysis | 2024

This study developed and validated a single VAMS workflow for measuring six antibiotics in critically ill children. Multiple drugs could be quantified from one microsample, supporting pharmacokinetic and precision-dosing studies.

Validation of Mitra((R)) VAMS((R)) as a blood collection technique for trace elements analysis using ICP-MS/MS

Breton, A.; Cirtiu, C. M.; Muehlethaler, C.; Rudge, J.; Fleury, N.
Bioanalysis | 2024

This study validated VAMS blood collection for trace-element analysis by ICP-MS/MS. Results showed acceptable agreement with whole-blood measurements and supported further development as a less-invasive alternative to venipuncture for selected elements.

Is the stability of folates in dried blood microsamples sufficient to perform home-sampling studies?

Heughebaert, L.; Stove, C. P.
Analyst | 2024

This study evaluated folate stability in dried blood microsamples under conditions relevant to home collection. The findings support home-sampling feasibility but show that realistic stability testing remains essential for unstable analytes.

A miniaturized sample preparation method for routine elemental determination in whole blood using volumetric absorptive micro-sampling by ICP-QQQ

Schmidt, L.; Peterson, K.; Nunes, T. S.; Knap, M.; Petrick, L.; Landero-Figueroa, J. A.
Anal Bioanal Chem | 2024

This study developed a miniaturized VAMS and ICP-QQQ workflow for routine elemental analysis in whole blood. The method showed strong precision and accuracy for target elements while identifying background contamination limitations for selected metals.

Towards clinical adherence monitoring of oral endocrine breast cancer therapies by LC-HRMS-method development, validation, comparison of four sample matrices, and proof of concept

Jacobs, C. M.; Radosa, J. C.; Wagmann, L.; Zimmermann, J. S. M.; Kaya, A. C.; Aygun, A.; Edel, T.; Stotz, L.; Ismaeil, M.; Solomayer, E. F.; Meyer, M. R.
Anal Bioanal Chem | 2024

This study developed and validated LC-HRMS methods to monitor adherence to oral endocrine breast-cancer therapies across four sample matrices. Most analytes met validation requirements, although plasma remained the most suitable matrix because established reference concentrations are available.

Self-Sampling by Adolescents at Home: Assessment of the Feasibility to Successfully Collect Blood Microsamples by Inexperienced Individuals

Boffel, L.; Van Mensel, A.; Pauwels, J.; Den Hond, E.; Bessems, J.; Van Uytfanghe, K.; Stove, C. P.
AAPS J | 2024

This study assessed whether inexperienced adolescents could collect quality capillary blood microsamples at home using six devices. Most participants succeeded, although sample quality varied by device, and home self-sampling was received positively.

Development and validation of a bioanalytical method for the quantification of methotrexate from serum and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS

Opitz, P.; Fobker, M.; Fabian, J.; Hempel, G.
J Chromatogr A | 2024

This validation study developed an LC-MS method for measuring methotrexate and metabolites from capillary blood collected using VAMS. The method offers a lower-volume alternative for therapeutic drug monitoring in pediatric acute lymphoblastic leukemia care.

GenTegraRNA-NEO for Microsampling Tips

GenTegra
2024

This application note provides instructions for using GenTegraRNA-NEO to stabilize RNA collected with Mitra devices and VAMS tips at room temperature. Rehydrated reagent can treat up to 32 VAMS tips, or eight four-tip Mitra devices.

Microbiome metabolite quantification methods enabling insights into human health and disease

Roach, J.; Mital, R.; Haffner, J. J.; Colwell, N.; Coats, R.; Palacios, H. M.; Liu, Z.; Godinho, J. L. P.; Ness, M.; Peramuna, T.; McCall, L. I.
Methods | 2024

This article reviews methods for quantifying microbiome-derived metabolites in human health and disease research. It highlights analytical strategies that can improve understanding of host-microbiome interactions and disease mechanisms.

Utilising volumetric absorptive microsampling (VAMS®) technology to monitor tacrolimus and creatinine concentrations in adult renal transplant patients

Miss Rosalyn Dunstan, Mrs Rebecca Allcock, Prof Alexander Woywodt, Dr Kina Bennett
2023

This thesis evaluates VAMS technology for monitoring tacrolimus and creatinine in adult renal transplant patients. The findings support the potential implementation of Mitra devices for therapeutic drug monitoring and other clinically relevant analytes.

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