microsampling in omics research
Volumetrically precise microsampling enables the analysis of thousands of molecules from minimal blood volumes. This approach allows researchers to capture individual omics profiles, offering comprehensive insights into human health. Microsampling also facilitates access to high-quality samples for genomics, proteomics, metabolomics, lipidomics, and transcriptomics research.
Advancing RNA Biomarker Research in Human Pre-Clinical Studies
Mitra® microsampling technology, now incorporated into Cellecta’s DriverMap™ RNA sequencing kits, is revolutionizing biomarker discovery by enabling efficient and scalable blood collection for pre-clinical human studies. With precise volumetric sampling and robust RNA stabilization, Mitra allows for high-resolution, reproducible transcriptome profiling, resulting in minimal variability and accurate outcomes.
Introducing GenTegraRNA-NEO for Stable RNA Preservation with Mitra Microsampling Devices
The new GenTegraRNA-NEO is an Active Chemical Protection™ (ACP) technology developed by GenTegra expressly for the Mitra® microsampling device and 96-Autorack™. Mitra devices that are pre-treated with GenTegraRNA-NEO before sampling will keep RNA stable in blood samples for up to 7 days at room temperature. The GenTegraRNA-NEO is for research use only (RUO).
Metabolon and Trajan Collaborate to Offer Microsampling for Metabolomics Studies
Metabolon validated a method for metabolomic profiling in blood microsamples collected using Trajan’s Neoteryx® Mitra® device based on VAMS® technology. Mitra devices, paired with Metabolon’s Global Discovery Panel, enable precise metabolomic analysis in blood samples acquired remotely from diverse sources and study subjects for research.
Promega Provides App Note for Automated RNA Purification on Trajan Microsampling Devices for RNA-based Studies
Researchers at Promega have published an application note demonstrating a method for purifying Total RNA, including miRNA, from whole blood collected on the VAMS® tips of Trajan’s Neoteryx Mitra® devices treated with GenTegraRNA-NEO™ solution using the Promega Maxwell® RSC simplyRNA Blood Kit and Maxwell® RSC Instrument.
Microsampling User Guide
This technical user guide is designed to get you started with microsampling. The printed guidance from our technical director helps you make initial decisions on best practices for achieving solid analytical validations in your research projects. What microsample volume is needed for your assay? What analyte classes are compatible with microsampling? How do you process microsamples in the lab? Download the guide to find answers to these questions, and more!
Frequently Asked Questions (FAQs)
Trajan microsampling devices are supporting omics research at leading institutions worldwide. They have contributed to multi-omics studies led by Dr. Steve Pennington of Atturos and his team in the HIPPOCRATES arthritis project in Europe.
In the United States, Dr. Jenny Van Eyk at Cedars-Sinai Medical Center and Dr. Mike Snyder at Stanford University School of Medicine have also utilized our devices in their omics research. These examples highlight how researchers are advancing multi-omics studies with our microsampling technologies.
Trajan microsampling technologies are utilized globally in omics research studies, clinical trials, therapeutic drug monitoring and so much more. The Technical Resource Library offers a searchable collection of published literature on omics research. To find relevant journal articles, presentations, and application notes from third-party experts, enter your keywords of interest in the library's search field.
Numerous analytes have been extracted using the Mitra® device with VAMS® microsampling technology. Published studies have demonstrated the compatibility of this technology with various testing protocols.
The literature and resources available on our website provide detailed information on the analytes extracted using our microsampling devices.
To locate relevant literature and case examples, please visit our Technical Resource Library and enter your analyte of interest in the search field.
Sample success rates vary based on the type of laboratory testing. However, published validation studies show that Trajan microsampling devices provide precise volumetric sampling and address the HCT issue often seen with DBS.
Studies also indicate that the absorptive VAMS® tips on Mitra® devices achieve 99% acceptance rates for homogenous samples.
By following the illustrated instructions and demo videos, end-users can reliably collect fixed-volume samples suitable for laboratory analysis.
Dried blood sampling is expanding as laboratories update testing methods and technology improves sensitivity and specificity. Research shows that dried capillary whole blood microsamples of 10, 20, or 30 µL provide sufficient material for effective extraction and analysis.
These samples often produce high-quality data comparable to venous blood. The literature includes case studies demonstrating microsampling in research.
Please visit the Technical Resource Library to review comparative studies on microsampling applications.
The first step in transitioning from other sampling methods to microsampling is an introductory, initial education phase, which may take about 4 weeks. The next steps involve evaluation and validation. Our Microsampling Team and Technical Director can provide support through all the steps:
Education: The introductory phase
Evaluation: Extraction, linearity & signal-to-noise studies
Validation: Validating your method
See our Microsampling User Guide for details.
Omics Blog Listing
Our website features many omics blogs discussing microsampling research in proteomics, metabolomics, lipidomics, genomics, and related studies. Click the button below to explore all of our omics blogs, gathered together in a single, curated list.
Microsampling in Proteomics Interview
James Rudge, PhD, interviews Stephen Pennington, BSc, PhD, a research scientist with expertise in using mass spectrometry to measure and characterize proteins. Learn how Dr. Pennington uses microsampling in proteomics and multi-center studies.
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