Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Researchers developed an online SPE-LC-MS method for apixaban, edoxaban, rivaroxaban, and dabigatran in 10 µL Mitra capillary-blood samples. The validated workflow showed no significant hematocrit effect and was designed for simple, cost-effective use in ambulatory care.
This analytical and clinical validation compared VAMS with conventional venous sampling for clofazimine monitoring in multidrug-resistant tuberculosis. Although a measurable bias required correction, VAMS was less expensive and showed potential for accessible remote clinical monitoring.
This human study used finger-prick VAMS and UPLC-MS/MS to follow polyphenol metabolites after consumption of purple whole-grain barley biscuits. Results agreed with venous plasma and revealed prolonged absorption patterns, supporting VAMS for less invasive nutrition pharmacokinetic studies.
This study combined VAMS, LC-MS/MS, and limited-timepoint sampling to estimate mycophenolate exposure in pediatric lupus-nephritis patients. Three finger-stick collections closely reproduced plasma pharmacokinetics, supporting less invasive precision dosing.
This study validated one analytical setup for measuring the alcohol biomarker PEth with Mitra and Capitainer volumetric microsamplers. Both devices met acceptance criteria and produced results that agreed acceptably with venous whole blood.
Researchers evaluated VAMS for collecting and stabilizing blood markers of exposure to nerve agents, sulfur mustard, and potent opioids. The analytical methods met sensitivity, precision, accuracy, and recovery requirements, supporting VAMS as a promising field-friendly collection method for chemical-threat verification.
Researchers developed and clinically validated a multi-matrix LC-MS/MS method for ganciclovir using qDBS, VAMS, and conventional samples in pediatric renal-transplant recipients. Strong agreement across matrices demonstrated the feasibility of both microsampling devices for routine therapeutic monitoring.
This feasibility study used VAMS to support large-scale blood-lead surveillance among children in two regions of the Republic of Georgia. The program confirmed persistent exposure concerns and demonstrated that VAMS can provide accurate, less invasive testing in settings with limited capacity for venous-sample handling and transport.
This scoping review examines the use of microsamples in mass-spectrometry-based proteomics. It found growing compatibility with standard bottom-up workflows while identifying a continuing need to standardize sample collection and quantification for large clinical cohorts.
This systematic review examined the economic evidence for microsampling-supported therapeutic drug monitoring. Available studies suggest possible cost savings, but evidence remains limited and rarely links costs with clinical outcomes.
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