Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This study validated a VAMS method for fosfomycin measurement in human whole blood. Accuracy, precision, linearity, selectivity, and matrix effects were acceptable, although recovery and stability findings identified challenges requiring further optimization.
This study developed and validated an LC-MS/MS method for emixustat in human whole blood collected by VAMS. The assay met requirements for accuracy, precision, selectivity, recovery, hematocrit effects, and stability.
This study evaluated Mitra sampling for E6005 and its metabolite and examined hematocrit-related recovery. Results showed that optimizing extraction to achieve high, hematocrit-independent recovery is essential for accurate VAMS bioanalysis.
This study compared two microsampling approaches for serial pharmacokinetic studies in rats. Capillary microsampling produced suitable concentration profiles and supported repeated low-volume blood collection during drug-discovery studies.
This study compared DBS and VAMS workflows for hepcidin measurement by microfluidic LC-MS/MS. Combining VAMS with phospholipid removal produced low matrix effects and high sensitivity, supporting a practical dried-blood assay.
This study compared VAMS with conventional DBS for caffeine and paraxanthine measurement across a range of hematocrit values. VAMS reduced hematocrit-related bias and produced robust results in incurred human samples.
This presentation describes a dried-matrix microsampling device designed to eliminate volume-based hematocrit bias associated with DBS sub-punch workflows. The device supports direct blood collection followed by drying and extraction through a simplified process.
This technical brief describes a protocol for pre-absorbing K2-EDTA anticoagulant onto a Mitra sampling tip before blood collection without affecting the device's volumetric properties.
This technical brief presents extraction protocols for blood collected with the Mitra microsampling device based on analyte LogP values. The recommended protocols typically provide extraction recoveries of 80% or greater with limited analyte-specific optimization.
This case report examined changing melanocytic nevi during BRAF-inhibitor therapy. An involuting nevus carried the BRAF V600E mutation while an unchanged nevus was BRAF wild type, supporting further study in larger cohorts.
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