Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Researchers compared nanofluidic LC-MS/MS with conventional UHPLC-MS/MS for measuring estradiol and estetrol after VAMS collection. The miniaturized LC-chip approach achieved substantially greater sensitivity while enabling whole-blood microsampling for small-animal pharmacokinetic studies.
Researchers evaluated VAMS with stable-isotope dilution LC-MS/MS for measuring whole-blood 5-methyltetrahydrofolate. The minimized collection approach was feasible for folate assessment and could support more efficient newborn or population screening after further optimization of background interference and automation.
Researchers developed an automated, high-throughput VAMS workflow for mass-spectrometric quantification of circulating protein biomarkers. Strong recovery, reproducibility, and long-term storage performance support its use for remote and personalized biomarker monitoring.
This study evaluated home-collected VAMS and dried blood spot samples for HbA1c monitoring in adults and children with diabetes. Results from dried microsamples showed poor agreement with hospital-based measurements, indicating that the tested workflow was not reliable for routine HbA1c monitoring.
This study combined VAMS with bead-based impact-assisted extraction for naproxen and ritonavir measurement. The extraction procedure produced quantitative recovery without hematocrit-related bias and met precision, accuracy, and matrix-effect criteria.
This study evaluated extraction solvents for VAMS samples across a wide hematocrit range. A methanol-acetonitrile workflow improved and stabilized analyte recovery while minimizing hematocrit-related effects.
This study introduced sponge-spray mass spectrometry for direct analysis from volumetric microsampling tips. The approach quantified penicillin G in plasma and urine with minimal sample preparation, demonstrating a rapid alternative for clinical analysis.
This study integrated VAMS into an untargeted mass-spectrometry metabolomics workflow and evaluated extraction and storage conditions. Acetonitrile-water extraction improved metabolite recovery, while frozen storage best preserved the dried-blood metabolome.
This presentation integrates protein extraction from Mitra tips into an automated bottom-up proteomics workflow. Protein recovery and digestion were reproducible, with further work focused on stability, cleanup, and clinical applications.
This presentation evaluates Mitra VAMS sampling for therapeutic drug monitoring and diagnostic biomarkers. It describes methotrexate and rheumatoid-factor assay development and supports capillary microsamples as a potential alternative to venous whole blood.
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