Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This article describes development of submillimetre devices for minimally invasive skin and blood sampling. It summarizes proposed applications in dermatology, infectious disease, longitudinal testing, paediatrics, and low-resource settings.
Skin microbiopsy samples and qPCR biomarker analysis were used to compare a superficial melanoma with a pigmented basal cell carcinoma. The case illustrates how spatially targeted molecular sampling may complement conventional diagnostic assessment.
This study validated an ELISA for quantifying saxitoxin in whole and dried human blood collected with microsampling devices. The method was sensitive, rapid, and accurate within validation limits, although product relevance should be confirmed because the abstract does not identify the collection-device brand.
Researchers developed and validated a VAMS–LC-MS/MS workflow for hydroxychloroquine and its metabolites in capillary blood from patients with rheumatoid arthritis. VAMS results supported accurate low-volume collection, simplified logistics, and the potential for patient sampling at home.
This study developed and validated a VAMS–UHPLC-MS/MS method for measuring estetrol in small whole-blood samples without derivatization. The method showed suitable sensitivity, accuracy, precision, and stability and performed well in two proof-of-concept pharmacokinetic studies in mice.
This study evaluated VAMS for quantifying tacrolimus in human whole blood across low, medium, and high hematocrit levels. The assay showed acceptable analytical performance and consistent recovery, while storage findings indicated that samples should remain frozen and that time-dependent recovery requires attention.
Researchers developed and validated a VAMS–LC-MS/MS method for measuring miltefosine in dried blood as an alternative to conventional dried blood spots. The method performed well and reduced hematocrit-related bias, although recovery still declined at higher hematocrit and clinical validation was recommended.
This study developed a VAMS–LC-MS/MS assay for simultaneous measurement of four antibiotics in 10 µL human blood and compared it with dried blood spots. The VAMS method was selective, precise, reproducible, and less affected by hematocrit, supporting pediatric pharmacokinetic studies and therapeutic drug monitoring.
Researchers developed and compared DBS and VAMS LC-MS/MS methods for natural and synthetic cannabinoids. The optimized dried-microsample protocols provide alternative tools for measuring THC, its major metabolites, and representative synthetic cannabinoids.
This study used 10 µL VAMS samples to support itraconazole pharmacokinetic studies while reducing blood volume and animal use. The method enabled repeated sampling from the same animals, although drug stability on the device was limited to 24 hours unless extracts were frozen.
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