Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This pilot study compared DBS and VAMS with plasma for measuring C-peptide as a marker of endogenous insulin secretion. Both microsampling methods agreed well with reference concentrations, with VAMS showing particularly strong short-term stability.
Researchers developed a GC-MS method for measuring salbutamol in 10 µL blood samples collected by VAMS. The assay was successfully applied after inhaled dosing and shows potential for therapeutic monitoring during severe pediatric asthma treatment.
This study compared VAMS with conventional dried blood spot sampling for monitoring several cardiovascular drugs by high-resolution mass spectrometry. The validated VAMS assay accurately identified medication adherence and showed strong agreement with DBS while producing fewer unusable samples.
This study used VAMS and mass-spectrometry metabolomics to characterize the effects of dietary iron overload in mice. Iron loading altered glucose metabolism, the Krebs and urea cycles, and oxidative-stress pathways over time.
This study evaluated VAMS for urinary metabolites relevant to alkaptonuria monitoring. Dried and liquid samples showed favorable accuracy and precision, although analyte-specific stability limitations remain a barrier to routine use.
This study developed a VAMS bioanalytical method and examined hematocrit-related bias for an investigational compound. Optimized extraction minimized bias across 30–60% hematocrit, and all validation parameters met acceptance criteria.
This study compared Mitra capillary microsampling with conventional dried-blood collection for estimating therapeutic-antibody concentrations. The resulting protocols supported practical conversion of capillary results to serum or plasma concentrations.
This study evaluated 10 µL VAMS samples for measuring perfluoroalkyl acids in whole blood. The method showed suitable sensitivity, repeatability, accuracy, and analyte stability for human biomonitoring studies.
This study developed and validated an LC-MS/MS method for four first-generation anti-epileptic drugs and one active metabolite in VAMS samples. Successful testing with quality-control and patient samples supported its use for therapeutic drug monitoring.
This presentation reviews patient-centric sampling technologies for quantitative bioanalysis. It highlights lower sample volumes, reduced discomfort, greater convenience, and the ability to collect clinically useful data in settings where conventional sampling is difficult.
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