Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This application note provides a workflow for purifying RNA from whole blood collected on 10, 20, or 30 µL VAMS tips in a Mitra device using the Maxwell RSC simplyRNA Blood Kit and Maxwell RSC Instrument.
This veterinary study compared microbiopsy, skin scraping, and tape stripping for minimally invasive skin sampling in dogs. All methods were feasible and well tolerated, but RNA yield, integrity, and contamination limited reliable downstream transcriptomic analysis.
This review compares minimally invasive skin-sampling methods through a fit-for-purpose framework and uses microbiopsy development as a translational case study. It concludes that microbiopsy can complement other approaches when subsurface material, spatial precision, or repeat sampling is important, but is not a universal replacement for conventional biopsy.
This work combines label-free multiphoton imaging with microbiopsy-based molecular and chemical assays to assess topical-product distribution and biological response in skin. Volunteer sunscreen and ex vivo diclofenac studies demonstrated localized imaging, qPCR, oxidative-stress, and quantitative exposure measurements at relevant sampling depths.
This study presents an image-guided microbiopsy workflow that combines clinical imaging, skin-surface phenotyping, and qPCR biomarkers to classify skin ageing. The authors report clinical feasibility and candidate molecular signals, while noting that the manuscript was reconstructed from supplied presentation data and requires further validation.
This paired pilot study compared skin microbiopsy and shave-biopsy specimens from actinic keratosis and basal cell carcinoma lesions for RNA sequencing. Microbiopsy yielded less starting RNA but produced sequenceable libraries and broadly concordant expression profiles, supporting further feasibility studies rather than diagnostic-equivalence claims.
Researchers developed an LC-MS/MS method for eight antiepileptic drugs and two metabolites using DBS and VAMS. Application to 80 paired patient samples showed promising relationships between microsampling and conventional plasma concentrations, including the first reported microsampling measurement of dihydroxycarbazepine.
This study evaluated VAMS-based processing for blood proteomics compared with conventional plasma and whole blood workflows. The VAMS-optimized approach increased protein identifications, improved reproducibility, and supported longitudinal biomarker discovery applications.
This metabolomics study compared Mitra, a comparator device, and dried blood spot microsampling with whole blood and plasma. Results showed blood microsampling profiles aligned more closely with whole blood than plasma and may support flexible human biomonitoring workflows.
This study used VAMS to characterize cefepime pharmacokinetics in critically ill children with multiple organ dysfunction syndrome. The work demonstrates the feasibility of microsampling-based antimicrobial PK modeling in pediatric critical care.
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