Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This study validated methods for measuring pediatric midazolam using wet whole blood and VAMS. Results supported VAMS as a suitable technique for pediatric pharmacokinetic studies.
This study analyzes everolimus in mitra VAMS blood samples for clinical research by turbulent flow LC-MS/MS and FAIMS-MS/MS.
This study examines wet absorptive microsampling at home for HbA1c monitoring in diabetic children.
This protocol describes a three-year prospective cohort study examining the epidemiology and biology of melanocytic nevi. Participants undergo repeated imaging and clinical assessment, with microbiopsy and excision planned for selected lesions to support histopathologic and molecular analyses.
Researchers developed an LC-MS/MS method for measuring acetylsalicylic acid in blood and compared conventional sampling with VAMS. The study found that VAMS samples required a stabilizing reagent to prevent concentration loss and support accurate analysis.
Researchers investigated hematocrit-related bias and apparent instability in VAMS assays and traced both problems to low and inconsistent extraction recovery. Optimizing recovery above 80% improved stability and hematocrit independence, leading to a recommended feasibility check for regulated bioanalysis.
This study compared conventional and miniaturized blood and urine sampling methods for LC-MS/MS measurement of oxycodone and its major metabolites. The validated dried-matrix approaches, including VAMS urine sampling, simplified collection and processing with acceptable precision and recovery, though lower sample volumes reduced sensitivity.
Researchers compared Mitra VAMS with dried blood spots for praziquantel pharmacokinetic sampling in children with schistosomiasis in rural Côte d’Ivoire. Mitra was practical and strongly correlated with DBS controls, but patient samples often produced higher concentrations and resulting pharmacokinetic estimates that require further investigation.
This review summarizes VAMS collection, storage, extraction, recovery, and analytical considerations for small-volume biological samples. It also surveys early pharmacokinetic and therapeutic drug-monitoring applications and highlights the roles of hematocrit, compound stability, and extraction optimization.
This preliminary study compared VAMS with cellulose-based microsampling materials for LC-MS protein analysis using six model proteins. Recovery varied by protein and hematocrit affected both VAMS and conventional material, while the initial VAMS results showed acceptable correlation, accuracy, and precision.
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