Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This case report describes how remote monitoring identified atrial fibrillation–atrial flutter in a patient with ischemic heart disease and enabled prompt treatment. Mitra-based monthly biomarker collection formed part of the broader patient-monitoring program, illustrating how patient-centric data collection may support earlier detection of cardiac events.
This study clinically validated dried-blood sampling for infliximab monitoring in inflammatory bowel disease. Home-sampled results correlated with serum concentrations and could support timely dose or interval adjustments.
This article reviews microsampling applications across pharmaceutical discovery and development. It outlines ethical and operational advantages and provides best-practice recommendations for nonclinical, clinical, and bioanalytical implementation.
This study developed and validated a VAMS–LC-MS/MS method for five immunosuppressants and evaluated hematocrit effects. The optimized extraction produced robust performance across the tested hematocrit and concentration ranges.
This study compared albendazole pharmacokinetics across plasma, whole blood, DBS, and Mitra samples in hookworm-infected adolescents. Concentration profiles were similar across matrices, and Mitra extraction showed greater robustness during validation.
This tutorial reviews the principles, procedures, and analytical workflows used in volumetric absorptive microsampling. It summarizes current applications and highlights technical considerations that still require further investigation.
This study developed a rapid touch-spray mass-spectrometry method for 30 drugs in oral fluid collected on volumetric swabs. The validated workflow produced acceptable quantitative results in under two minutes per sample, supporting point-of-care clinical and forensic testing.
This study evaluated the volume accuracy, hematocrit independence, and clinical performance of the hemaPEN dried-blood device. Successful cross-laboratory validation and patient-sample testing supported its potential for volumetric DBS collection.
This study developed a home-based VAMS method for monitoring mitotane concentrations. Dried-blood results correlated poorly with plasma, indicating that routine use would require a method-specific therapeutic target range.
This study developed and validated LC-MS/MS methods for paracetamol in dried blood and dried cerebrospinal fluid collected with VAMS. Quality-control and patient-sample testing demonstrated valid performance and provided proof of concept for CSF microsampling.
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