Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Researchers developed and validated an LC-MS/MS assay for measuring vancomycin and creatinine in plasma applied to VAMS devices. Both analytes remained stable for two weeks at elevated temperature, and correction equations enabled estimation of plasma concentrations for therapeutic monitoring in resource-limited settings.
Researchers developed an LC-MS/MS method for measuring iohexol in 10 µL capillary blood samples collected with VAMS and also evaluated the HemaPEN device. Iohexol remained stable in dried VAMS samples for up to 12 days, supporting minimally invasive and potentially delayed testing for glomerular filtration-rate assessment.
Researchers combined VAMS with the multiplex mPlex-Flu assay to measure antibodies against multiple influenza strains. At-home finger-stick samples agreed closely with venous serum, remained stable during storage and shipping, and supported scalable population or clinical-trial monitoring.
Researchers validated a VAMS LC-MS/MS method for everolimus and applied it clinically. Although the assay met validation criteria, hematocrit-related bias remained substantial and required an empirical correction to estimate whole-blood concentrations accurately.
Researchers developed and validated a VAMS assay for voriconazole and its N-oxide metabolite in whole blood. The method provided suitable stability and analytical performance for implementation in a pediatric pharmacokinetic study.
Researchers developed a patient-centric VAMS LC-MS/MS assay for THC, cannabidiol, and cannabinol in whole blood. The analytes remained stable under multiple storage conditions, and the method was prepared for use in pediatric pharmacokinetic trials.
This feasibility study evaluated microsampling for cyclosporine, everolimus, sirolimus, and tacrolimus monitoring. Precision and bias remained within 15% across the tested immunosuppressants, supporting further clinical use of small-volume sampling.
Researchers transitioned methotrexate-polyglutamate therapeutic monitoring from venous red blood cells to finger-stick capillary blood. After clinical implementation, the capillary method produced comparable results and identified underexposure at rates similar to conventional testing.
This animal study examined how fetal growth restriction caused by a low-protein maternal diet affects placental and neuroendocrine corticosterone regulation. The findings suggest adaptive fetal responses that may preserve brain development but could contribute to later neurodevelopmental effects.
This preclinical study compared tacrolimus pharmacokinetics measured from VAMS, wet whole blood, and plasma in rats. VAMS and whole-blood concentrations agreed well, and pharmacokinetic parameters were comparable across matrices, supporting VAMS for small-volume animal studies.
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