Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This clinical study used repeated skin microbiopsy sampling to evaluate molecular changes in photoaged skin after topical treatment. The approach enabled temporal and spatial gene-expression measurements and was intended to reduce the burden associated with conventional biopsies.
This review compares current skin- and blood-microsampling techniques, including their benefits, analytical limitations, and potential point-of-care applications. It also discusses the broader effects of less-invasive sampling on access, turnaround time, and patient care.
This study developed and validated a VAMS–LC-MS/MS method for measuring 14 antiepileptic drugs and two active metabolites in whole blood. The assay was accurate, precise, stable across a broad temperature range, and showed no volumetric hematocrit bias, supporting therapeutic drug monitoring applications.
This official guideline defines development, analytical validation, clinical validation, and routine-use requirements for dried-blood-spot therapeutic drug-monitoring methods. It covers DBS-specific issues such as sample volume, hematocrit, spot quality, collection procedures, comparison with venous blood, and cross-validation.
Researchers optimized VAMS–mass-spectrometry analysis of 36 metabolites from 10 µL whole-blood samples. The method detected all targets with good repeatability, and dried samples remained stable at room temperature longer than wet blood.
Researchers profiled seasonal variation in blood-borne microRNAs and validated the findings in 919 samples collected with the Mitra home-sampling device. Spring-to-fall differences involved immune-related microRNAs, indicating that season may confound diagnostic or prognostic signatures.
This study compared quantitative fatty-acid measurement from conventional dried-blood cards, a 10 µL wicking device, and wet blood. Dried-sample results were broadly similar to wet blood, supporting concentration-based reporting alongside relative fatty-acid percentages.
This phase I study compared conventional venous, Mitra, and Aqua-Cap microsampling for radiprodil pharmacokinetics in healthy adults. Overall exposure estimates were comparable, although Mitra produced somewhat lower values, supporting future use of microsampling in pediatric studies.
Researchers used low-input RNA sequencing of blood cells from 21 animal species to characterize circulating small noncoding RNAs. The work found strong evolutionary conservation and created a publicly searchable atlas of species- and family-level expression profiles.
This protocol describes the PRE-MACE study, which combines wearable sensors, patient-reported outcomes, plasma biomarkers, and at-home blood microsampling in people with stable ischemic heart disease. The study tests whether remote monitoring can identify early warning signals for major adverse cardiac events and reduce resource use.
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