Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This study developed and validated an online-preparation VAMS–UHPLC-MS/MS method for cannabidiol and THC in capillary blood. Results from pediatric patients agreed with venous blood and plasma, and samples remained stable for four weeks at room temperature, supporting therapeutic monitoring.
Researchers combined blood or plasma VAMS, rapid dispersive-pipette extraction, and LC-MS/MS to measure cocaine and major metabolites. The method showed strong recovery, precision, two-month room-temperature stability, and good agreement with fluid samples for forensic and anti-doping use.
Researchers standardized a highly specific ELISA protocol for SARS-CoV-2 serosurveys using both conventional serum and mail-in dried-blood samples. Validation showed minimal coronavirus cross-reactivity and supported reliable population estimates from clinical and at-home collection.
This review examines dried-matrix spots, VAMS, microfluidic and capillary sampling, and solid-phase microextraction in the context of SARS-CoV-2 research and care. It summarizes the benefits, limitations, and available applications of microsampling for diagnostic, therapeutic, and monitoring workflows.
This study developed and validated a VAMS–LC-MS/MS method using UniSpray ionization for five common immunosuppressants in venous blood. The assays met analytical criteria, showed no meaningful hematocrit effect, and produced concentrations that correlated with the original liquid samples.
Researchers combined VAMS collection of whole blood and oral fluid with microextraction and HPLC analysis for four antidepressants and their metabolites. The validated method produced results consistent with conventional fluid samples, supporting simpler storage and potential at-home therapeutic drug monitoring.
This review examines the opportunities and limitations of dried blood spots and VAMS in regulated bioanalysis. It highlights benefits for low-volume, remote, pediatric, pharmacokinetic, and toxicokinetic sampling while discussing hematocrit, sample homogeneity, repeat analysis, and regulatory acceptance.
Researchers developed two methods to estimate hematocrit from the potassium content of a VAMS sample. Both approaches can be integrated with existing VAMS assays, allowing target-analyte measurement and hematocrit estimation from the same extract when blood results must be related to plasma or serum values.
Researchers developed a dried-blood-spot method for measuring vedolizumab and compared it with paired venous serum samples from treated patients. DBS concentrations correlated strongly with serum values, supporting less invasive intensive sampling for therapeutic drug monitoring and pharmacokinetic studies.
This study developed a microsampling GC-MS/MS method for anabolic steroids and applied it after testosterone-gel administration. Dried-blood testosterone showed strong sensitivity to transdermal micro-dosing, supporting broader anti-doping surveillance applications.
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