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Microsampling Publications Library

Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.  

Search results are matched to the publication record, including title, abstract, keywords, authors, and other indexed details. All search terms must appear in the record for it to be included in your results.

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Detection of anti-SARS-CoV-2 antibodies in dried blood spots utilizing manual or automated spot extraction and electrochemiluminescence immunoassay (ECLIA)

Knoop, A.; Geyer, H.; Lerch, O.; Rubio, A.; Schrader, Y.; Thevis, M.
Anal Sci Adv | 2021

This study compared anti-SARS-CoV-2 antibody results from home-collected dried blood with conventional venous samples using an electrochemiluminescence immunoassay. The methods showed comparable performance, and repeat testing indicated persistent antibodies up to ten months after infection.

Evaluation and analytical applicability of a novel volumetric absorptive microsampling strategy for adherence monitoring of antihypertensive drugs by means of LC-HRMS/MS

Jacobs, C. M.; Kunz, M.; Mahfoud, F.; Wagmann, L.; Meyer, M. R.
Anal Chim Acta | 2021

This study developed a VAMS–LC-HRMS/MS method to monitor adherence to ten commonly prescribed antihypertensive drugs. The workflow was successfully validated for most analytes and performed consistently across hematocrit levels.

Patient-Centric Assessment of Thiamine Status in Dried Blood Volumetric Absorptive Microsamples Using LC-MS/MS Analysis

Verstraete, J.; Stove, C.
Anal Chem | 2021

This study developed LC-MS/MS methods to assess thiamine status in dried VAMS and liquid blood. Comparable results and successful testing in healthy volunteers supported the method’s validity for patient-centric nutritional assessment.

Development, validation, and application of a quantitative volumetric absorptive microsampling-based method in finger prick blood by means of LC-HRMS/MS applicable for adherence monitoring of antipsychotics

Jacobs, C. M.; Wagmann, L.; Meyer, M. R.
Anal Bioanal Chem | 2021

This study developed and evaluated a VAMS-based method for measuring 13 frequently prescribed antipsychotics in finger-prick blood. The workflow was successfully validated for most analytes across multiple hematocrit levels and supported adherence monitoring.

Volumetric absorptive microsampling (VAMS) as a reliable tool to assess thiamine status in dried blood microsamples: a comparative study

Verstraete, J.; Stove, C.
Am J Clin Nutr | 2021

This study compared thiamine measurements from capillary and venous VAMS samples with conventional liquid blood. The methods showed strong agreement, supporting one-drop finger-prick VAMS as a reliable patient-centric tool for assessing thiamine status.

Development and Validation of the Quantification Method for Hydroxychloroquine in Volumetric Absorptive Microsampling (VAMS) Using High-Performance Liquid Chromatography-Photodiode Array

Harahap, Y.; Rohadatul 'Aisy, S. A.; Maggadani, B. P.
Adv Pharmacol Pharm Sci | 2021

This study developed and validated an HPLC-PDA method for hydroxychloroquine measurement in VAMS samples. The method met FDA validation criteria across a 2–6500 ng/mL calibration range, supporting therapeutic drug monitoring.

Automated Total RNA Purification from Blood on a Mitra Microsampler

Promega
2021

This application note describes purification of total RNA, including miRNA, from whole blood collected on Mitra microsamplers using the Maxwell RSC miRNA Plasma and Serum Kit and Maxwell RSC Instrument.

Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling

Al-Qurain, A. A.; Williams, D. B.; Mackenzie, L.; Roberts, M. S.; Wiese, M. D.
J Pharm Biomed Anal | 2021

This method development study quantified several opioids and metabolites in plasma, whole blood, and VAMS-collected blood. Results support accurate LC-MS/MS analysis across matrices, including whole blood collected using VAMS.

Towards a Universal Bioanalytical Workflow for VAMS

Altasciences
2020

This presentation explores a universal bioanalytical workflow for VAMS samples. Continuous polarity switching supported a single-assay approach in place of separate positive- and negative-ionization workflows.

Quantitation of the Monoclonal Antibody Rituximab Using VAMS, Impact-Assisted Extraction, Trypsin Digestion and LC-MRM

Altasciences
2020

This presentation examines quantitation of the monoclonal antibody rituximab using VAMS, impact-assisted extraction, trypsin digestion and LC-MRM. The developed assay demonstrated excellent linearity, precision and accuracy whilst negating hematocrit effect.

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