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Microsampling Publications Library

Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.  

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Multiplex Analysis of 230 Medications and 30 Illicit Compounds in Dried Blood Spots and Urine

Tagwerker, C.; Baig, I.; Brunson, E. J.; Dutra-Smith, D.; Carias, M. J.; de Zoysa, R. S.; Smith, D. J.
J Anal Toxicol | 2021

This study developed a broad dried-blood and urine assay covering 230 medications and 30 illicit compounds. Comprehensive DBS testing supported medication reconciliation, identified unexpected drug use, and enabled automated detection of potentially serious drug–drug interactions.

Analysis of tamoxifen and its metabolites in dried blood spot and volumetric absorptive microsampling: comparison and clinical application

Maggadani, B. P.; Harahap, Y.; Harmita,; Haryono, S. J.; Untu, C. W. P.
Heliyon | 2021

Researchers developed and compared DBS and VAMS UPLC-MS/MS methods for measuring tamoxifen and three metabolites in patients with breast cancer. Both microsampling approaches remained stable for up to two months and produced clinically comparable concentrations.

Efficacy and safety of moxidectin and albendazole compared to ivermectin and albendazole co-administration in adolescents infected with Trichuris trichiura: a randomized controlled trial protocol

Welsche, S.; Mrimi, E. C.; Keller, L.; Hurlimann, E.; Hofmann, D.; Hattendorf, J.; Ali, S. M.; Keiser, J.
Gates Open Res | 2021

This randomized-trial protocol compares moxidectin plus albendazole with ivermectin plus albendazole in adolescents infected with Trichuris trichiura. The study will assess efficacy, safety, longer-term infection prevalence, and pharmacokinetic–pharmacodynamic relationships to inform improved deworming programs.

Clinical Validation of a Volumetric Absorptive Micro-Sampling Device for Pharmacokinetic Studies With Tranexamic Acid

Grassin-Delyle, S.; Lamy, E.; Semeraro, M.; Runge, I.; Treluyer, J. M.; Mansukhani, R.; Arribas, M.; Roberts, I.; Shakur-Still, H.
Front Pharmacol | 2021

This clinical validation compared tranexamic-acid concentrations in VAMS capillary blood with paired venous samples. Agreement was sufficient across clinically relevant concentrations, supporting VAMS for pharmacokinetic studies of tranexamic-acid treatment.

Blood Microsampling to Monitor Metabolic Profiles During Physical Exercise

Nix, C.; Hemmati, M.; Cobraiville, G.; Servais, A. C.; Fillet, M.
Front Mol Biosci | 2021

This study used hemaPEN microsampling and targeted metabolomics to track amino-acid and organic-acid changes before, during, and after exercise. The pilot identified expected metabolic shifts and demonstrated a convenient approach for collecting, storing, and processing samples during sporting activity.

Antibody Mediated Immunity to SARS-CoV-2 and Human Coronaviruses: Multiplex Beads Assay and Volumetric Absorptive Microsampling to Generate Immune Repertoire Cartography

Wang, J.; Li, D.; Zhou, Q.; Wiltse, A.; Zand, M. S.
Front Immunol | 2021

Researchers combined VAMS with a multiplex bead assay to map antibody responses to SARS-CoV-2 and seasonal human coronaviruses. Finger-stick results distinguished pre-pandemic, convalescent, and vaccinated groups, supporting remote population studies of multidimensional coronavirus immunity.

Microsampling: A role to play in Covid-19 diagnosis, surveillance, treatment and clinical trials

Rajadhyaksha, M.; Londhe, V.
Drug Test Anal | 2021

This review examines how microsampling supported COVID-19 diagnosis, surveillance, therapeutic monitoring, treatment development, and clinical trials. Validated assays and stable dried samples reduced dependence on clinical staff while enabling population-scale and remote testing.

EPO transgene detection in dried blood spots for antidoping application

Marchand, A.; Roulland, I.; Semence, F.; Ericsson, M.
Drug Test Anal | 2021

This study developed a dried-blood method for detecting an EPO transgene in anti-doping applications. The assay detected 1,000 transgene copies from 20 µL samples across three collection formats, with slightly greater sensitivity for VAMS and no loss after one month at room temperature.

Volumetric Absorptive Microsampling as a New Biosampling Tool for Monitoring of Tamoxifen, Endoxifen, 4-OH Tamoxifen and N-Desmethyltamoxifen in Breast Cancer Patients

Maggadani, B. P.; Harmita,; Haryono, S. J.; Rinaldi, M. R.; Harahap, Y.
Drug Des Devel Ther | 2021

Researchers developed and validated a VAMS LC-MS/MS method for simultaneous measurement of tamoxifen and three active metabolites. The analytes remained stable for up to 30 days at room temperature, and the method was successfully applied to samples from 30 patients with breast cancer.

Innovative methods for remote assessment of neurobehavioral development

Gustafsson, H. C.; Young, A. S.; Stamos, G.; Wilken, S.; Brito, N. H.; Thomason, M. E.; Graham, A.; Nigg, J. T.; Sullivan, E. L.
Dev Cogn Neurosci | 2021

This report describes remote methods developed to assess neurobehavioral development, parent–child interaction, and family health when in-person research was restricted. The protocols were successfully distributed to eight U.S. research sites and may offer lasting advantages for decentralized developmental studies.

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