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Microsampling Publications Library

Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.  

Search results are matched to the publication record, including title, abstract, keywords, authors, and other indexed details. All search terms must appear in the record for it to be included in your results.

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Tacrolimus Measured in Capillary Volumetric Microsamples in Pediatric Patients-A Cross-Validation Study

Kindem, I. A.; Bjerre, A.; Asberg, A.; Midtvedt, K.; Bergan, S.; Vethe, N. T.
Ther Drug Monit | 2021

This cross-validation study compared VAMS and venous tacrolimus measurements in pediatric solid-organ transplant recipients. The methods showed close agreement before and after dosing, supporting the feasibility of home-based tacrolimus monitoring for children.

Quantitation of phosphatidylethanol in dried blood after volumetric absorptive microsampling

Van Uytfanghe, K.; Ramirez Fernandez, M. D. M.; De Vos, A.; Wille, S. M.; Stove, C. P.
Talanta | 2021

Researchers developed VAMS–LC-MS/MS methods for phosphatidylethanol, a direct marker of alcohol intake, and compared results between two laboratories. The final methods were reproducible and closely aligned, while the work identified calibration and transition-selection issues important for broader standardization.

A high-throughput microfluidic nanoimmunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultralow-volume blood samples

Swank, Z.; Michielin, G.; Yip, H. M.; Cohen, P.; Andrey, D. O.; Vuilleumier, N.; Kaiser, L.; Eckerle, I.; Meyer, B.; Maerkl, S. J.
Proc Natl Acad Sci U S A | 2021

Researchers developed a high-throughput microfluidic nanoimmunoassay for SARS-CoV-2 antibodies and paired it with ultralow-volume finger-prick collection. The platform achieved high sensitivity and specificity while using minimal reagent, supporting decentralized serology and broader protein-biomarker testing.

Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?

D'Urso, A.; Locatelli, M.; Tartaglia, A.; Molteni, L.; D'Ovidio, C.; Savini, F.; Rudge, J.; de Grazia, U.
Pharmaceuticals (Basel) | 2021

This review evaluates published applications of Mitra VAMS for therapeutic monitoring of antiseizure medications. It highlights minimally invasive home collection and reduced hematocrit effects while noting that stability and performance remain drug-specific.

Lessons Learned From Conducting Internet-Based Randomized Clinical Trials During a Global Pandemic

Pullen, M. F.; Pastick, K. A.; Williams, D. A.; Nascene, A. A.; Bangdiwala, A. S.; Okafor, E. C.; Hullsiek, K. H.; Skipper, C. P.; Lofgren, S. M.; Engen, N.; Abassi, M.; McDonald, E. G.; Lee, T. C.; Rajasingham, R.; Boulware, D. R.
Open Forum Infect Dis | 2021

This article reports lessons from rapidly launching nationwide internet-based randomized clinical trials during the COVID-19 pandemic. Online screening, enrollment, outcomes, and follow-up enabled recruitment of 2,795 participants and informed recommendations for future remote trials.

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

Shan, D.; Johnson, J. M.; Fernandes, S. C.; Suib, H.; Hwang, S.; Wuelfing, D.; Mendes, M.; Holdridge, M.; Burke, E. M.; Beauregard, K.; Zhang, Y.; Cleary, M.; Xu, S.; Yao, X.; Patel, P. P.; Plavina, T.; Wilson, D. H.; Chang, L.; Kaiser, K. M.; Nattermann, J.; Schmidt, S. V.; Latz, E.; Hrusovsky, K.; Mattoon, D.; Ball, A. J.
Nat Commun | 2021

This study evaluated a sensitive immunoassay for SARS-CoV-2 nucleocapsid protein in venous and capillary blood and saliva. The assay showed strong agreement with molecular testing early in infection and may support swab-free at-home or point-of-care collection.

Standardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling

Klumpp-Thomas, C.; Kalish, H.; Drew, M.; Hunsberger, S.; Snead, K.; Fay, M. P.; Mehalko, J.; Shunmugavel, A.; Wall, V.; Frank, P.; Denson, J. P.; Hong, M.; Gulten, G.; Messing, S.; Hicks, J.; Michael, S.; Gillette, W.; Hall, M. D.; Memoli, M. J.; Esposito, D.; Sadtler, K.
Nat Commun | 2021

This study standardized a highly specific SARS-CoV-2 ELISA protocol using conventional serum and mail-in dried-blood samples. Validation showed minimal cross-reactivity and supported reliable population measurement of infection, seropositivity, and immunity.

The Evolving Role of Microsampling in Therapeutic Drug Monitoring of Monoclonal Antibodies in Inflammatory Diseases

Mingas, P. D.; Zdovc, J.; Grabnar, I.; Vovk, T.
Molecules | 2021

This review examines dried blood spots and newer microsampling approaches for therapeutic monitoring of monoclonal antibodies used in inflammatory disease. Home sampling offers practical advantages, but hematocrit and clinical validation remain important barriers to routine adoption.

Volumetric Absorptive Microsampling of Blood for Untargeted Lipidomics

Marasca, C.; Arana, M. E. B.; Protti, M.; Cavalli, A.; Mercolini, L.; Armirotti, A.
Molecules | 2021

This proof-of-concept study compared VAMS, dried blood spots, and fluid blood for untargeted lipid profiling by high-resolution LC-MS/MS. VAMS captured a broad lipid profile and appeared viable for lipidomics, although further characterization is needed.

Antigen-based multiplex strategies to discriminate SARS-CoV-2 natural and vaccine induced immunity from seasonal human coronavirus humoral responses

Laing, E. D.; Sterling, S. L.; Richard, S. A.; Epsi, N. J.; Coggins, S.; Samuels, E. C.; Phogat, S.; Yan, L.; Moreno, N.; Coles, C. L.; Drew, M.; Mehalko, J.; English, C. E.; Merritt, S.; Mende, K.; Munster, V. J.; de Wit, E.; Chung, K. K.; Millar, E. V.; Tribble, D. R.; Simons, M. P.; Pollett, S. D.; Agan, B. K.; Esposito, D.; Lanteri, C.; Clifton, G. T.; Mitre, E.; Burgess, T. H.; Broder, C. C.
medRxiv | 2021

This study developed multiplex antibody assays using SARS-CoV-2 and seasonal-coronavirus antigens to distinguish vaccination, natural infection, and cross-reactive immunity. The antigen-dependent assays achieved high sensitivity and specificity and may support surveillance as vaccination becomes widespread.

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