Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This study compared antibody responses induced by the BNT162b2, mRNA-1273, and Sputnik V COVID-19 vaccines with responses after natural infection. All three vaccines generated strong receptor-binding-domain antibodies, while the data also reinforced the importance of completing multi-dose regimens.
This study evaluated VAMS with direct mercury analysis for biomonitoring exposure in German adults. The method showed strong accuracy and precision, particularly at higher concentrations, supporting it as a viable alternative to venous blood collection.
Researchers developed a rapid ELISA-based screening method for detecting continuous erythropoietin receptor activator in dried blood spots. The approach detected CERA for up to 20 days after administration and successfully identified the drug in authentic doping-control samples.
Researchers developed MOG analogues to investigate MCT2 transport, α-ketoglutarate biology, and the cellular effects of N-oxalylglycine. Selected compounds retained cellular entry and prolyl-hydroxylase inhibition without inhibiting glutaminolysis or causing cytotoxicity, helping separate the compound’s overlapping biological effects.
This position paper considers how patient-centric sampling can support clinical drug development and decentralized trials. It outlines potential benefits for participants and sponsors alongside bioanalytical, operational, regulatory, and program-planning requirements.
This study characterized the population pharmacokinetics of moxidectin in adults infected with Strongyloides stercoralis using serial microsamples. Model-based simulations found similar exposure with fixed and weight-based regimens, supporting a simpler fixed-dose approach for large-scale treatment programs.
This clinical study evaluated a VAMS-based method for measuring paracetamol and four metabolites in obese and non-obese patients. Finger-prick samples provided results suitable for pharmacokinetic analysis, supporting a less burdensome alternative to conventional venous sampling.
This study established standardized, automated proteomics workflows for naïve plasma, depleted plasma, and dried blood. The high- and mid-throughput approaches produced reproducible protein measurements across a broad dynamic range, supporting scalable biomarker-discovery studies.
This study validated DBS and VAMS methods for simultaneous tacrolimus and creatinine measurement after kidney transplantation. Corrected VAMS results agreed closely with venous samples and supported VAMS as the preferred single-sample option.
This study evaluated dabrafenib and trametinib exposure and the feasibility of at-home capillary blood sampling in patients with melanoma. Self-sampling was practical, and a conversion model estimated serum pharmacokinetic parameters from microsamples.
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