Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This proof-of-concept study examined associations between anxiety, depression, and SARS-CoV-2 antibody status. The findings provided preliminary support for a relationship between psychological factors and infection susceptibility, although the individual measures were not independent predictors after adjustment.
This pilot study evaluated home VAMS and rapid lateral-flow testing for therapeutic monitoring of adalimumab. Capillary and venous VAMS measurements correlated strongly with serum, and rapid-test results agreed well with ELISA, supporting further implementation research.
Researchers developed a VAMS LC-MS/MS method for 5-fluorouracil, capecitabine, and related metabolites in patients receiving cancer treatment. Microsampling performed comparably to conventional collection and may enable better-timed, less invasive therapeutic monitoring for dose optimization.
This review examines VAMS for therapeutic drug monitoring of immunosuppressive medications, from sampling and analytical challenges through clinical implementation. It identifies key strengths and limitations and highlights potential benefits for treatment adherence, particularly in pediatric patients.
This study implemented pooled PCR surveillance for asymptomatic SARS-CoV-2 infection at a veterinary teaching hospital and assessed antibody status at study completion. The strategy enabled large-scale testing with substantial cost savings and identified both vaccine- and infection-associated antibodies in participants.
Researchers validated dried VAMS and other microsampling approaches for measuring clozapine and its major metabolites in psychiatric patients. The methods showed strong recovery, precision, and stability, and agreed well with conventional plasma analysis in clinical samples.
This preclinical study evaluated the metabolic effects of the soluble guanylate-cyclase stimulator praliciguat in diet-induced obese mice. Treatment increased energy utilization, improved insulin sensitivity, and lowered plasma triglycerides, with associated restoration of liver signaling.
Researchers developed a VAMS LC-MS/MS method for measuring cannabidiol, THC, and major metabolites after controlled administration in patients with epilepsy. The assay quantified the target compounds from only 30 µL of blood, enabling minimally invasive pharmacokinetic investigation.
Researchers developed and validated a UPLC-MS/MS method for measuring cyclophosphamide and its active metabolite in VAMS samples. The assay met FDA bioanalytical requirements across wide calibration ranges, supporting small-volume pharmacokinetic and therapeutic studies.
This review examines dried-blood microsampling for therapeutic drug monitoring of tyrosine kinase inhibitors in oncology. It discusses analytical validation, stability, hematocrit effects, blood-to-plasma conversion, quality controls, and the practical feasibility of home sampling.
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