Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Researchers measured SARS-CoV-2 and seasonal-coronavirus antibodies in longitudinal milk and finger-stick blood samples from lactating parents after vaccination or infection. Both exposures increased cross-reactive IgG, suggesting that milk may provide infants with passive immunity beyond SARS-CoV-2.
This longitudinal study evaluated a nucleocapsid-containing antibody assay for distinguishing natural SARS-CoV-2 infection from vaccination in capillary-blood samples. Nucleocapsid response accurately predicted recent infection among partially vaccinated participants, while a spike-only assay lacked specificity after vaccination.
This study used capillary microsampling and targeted metabolomics to examine changes in 35 metabolites after a simulated 21-km trail race. Metabolic responses varied with training level and performance, demonstrating the value of microsampling-based metabolomics for studying exercise adaptation.
Researchers used community venue-based sampling and finger-stick antibody testing to estimate SARS-CoV-2 exposure in Essex County, New Jersey. The measured burden was substantially higher than PCR reporting suggested, and observed outcome disparities appeared more related to upstream health and care factors than exposure.
This study evaluated VAMS as a preparation matrix for LC-MS proteomic analysis of dried whole blood in precision-medicine research. The workflow quantified up to 1,600 proteins and also supported analysis of long-stored blood-cell pellets, demonstrating potential for large-scale biomarker studies.
Researchers combined VAMS, automated sample preparation, and data-independent mass-spectrometry acquisition to assess hemoglobin-related clinical markers. HbA1c correlated with the reference method but did not meet imprecision requirements, while a customized workflow enabled identification of hemoglobin variants.
This study developed and validated a VAMS–LC-MS/MS method for ten kinase inhibitors and established in-vitro conversion factors between VAMS and plasma concentrations. The assay met analytical criteria, remained stable for at least six weeks, and was successfully applied to samples collected in clinics and at home.
Researchers clinically compared dried blood spots and Mitra VAMS with conventional matrices for tacrolimus and mycophenolic-acid monitoring. Although both microsampling approaches showed similar analytical performance, DBS performed better against clinical acceptance criteria, sample quality, and cost in this study.
Researchers developed and validated online solid-phase-extraction LC-MS methods for measuring axitinib in plasma and 10 µL capillary VAMS samples. The workflow was reliable and cost-efficient across clinically relevant ranges, supporting therapeutic drug monitoring in ambulatory and clinical care.
This article describes how perinatal researchers adapted prospective studies during the COVID-19 pandemic through remote recruitment, virtual consent, wearable monitoring, and participant self-collection of biological samples. The authors conclude that these approaches can broaden access and participation among pregnant and postpartum populations while supporting more flexible, inclusive research.
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