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Microsampling Publications Library

Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.  

Search results are matched to the publication record, including title, abstract, keywords, authors, and other indexed details. All search terms must appear in the record for it to be included in your results.

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The effect of needle length and skin to deltoid muscle distance in adults receiving an mRNA COVID-19 vaccine

Hills, T.; Paterson, A.; Woodward, R.; Middleton, F.; Carlton, L. H.; McGregor, R.; Barfoot, S.; Ramiah, C.; Whitcombe, A. L.; Zimbron, V. M.; Mahuika, D.; Brown, J.; Palmer-Neels, K.; Manning, B.; Jani, D.; Reeves, B.; Whitta, G. T.; Morpeth, S.; Beasley, R.; Weatherall, M.; Jordan, A.; McIntyre, P.; Moreland, N. J.; Mirjalili, S. A.
Vaccine | 2022

This observational study examined whether injection-needle length and skin-to-muscle distance affected antibody responses after mRNA COVID-19 vaccination. Antibody levels were comparable across needle-sufficiency groups, but the specific product used for the finger-prick blood collection is not identified in the abstract and requires confirmation.

Stability of acetylsalicylic acid in human blood collected using volumetric absorptive microsampling (VAMS) under various drying conditions

Moon, S. J.; Han, S. H.; Kwak, Y. G.; Kim, M. G.
Transl Clin Pharmacol | 2022

This study investigated the instability of acetylsalicylic acid in VAMS samples under different drying conditions. Controlling humidity increased recovery above 85%, and a household vacuum sealer offered a practical approach for stabilizing patient-collected samples at home.

Optimization of Aflatoxin B(1)-Lysine Analysis for Public Health Exposure Studies

Renaud, J. B.; Walsh, J. P.; Sumarah, M. W.
Toxins (Basel) | 2022

Researchers optimized digestion and analysis of the aflatoxin B1–lysine biomarker and developed a reference material to support method comparison. VAMS samples produced results equivalent to serum, supporting dried microsampling for public-health exposure studies.

Quantitative serology for SARS-CoV-2 using self-collected saliva and finger-stick blood

Campbell, C.; Padmanabhan, N.; Romero, D.; Joe, J.; Gebremeskel, M.; Manjula, N.; Wohlstadter, N.; Wohlstadter, R.; Goodwin, P.; Quintero, L.; Debad, J.; Sigal, G.; Wohlstadter, J.
Sci Rep | 2022

This study adapted quantitative SARS-CoV-2 serology assays for self-collected finger-stick blood and saliva. Both sample types identified prior immune responses with high specificity, and saliva remained stable for five days, supporting scalable mail-based testing.

Analysis of accumulated SARS-CoV-2 seroconversion in North Carolina: The COVID-19 Community Research Partnership

Williamson, J. C.; Wierzba, T. F.; Santacatterina, M.; Munawar, I.; Seals, A. L.; Pittman Ballard, C. A.; Alexander-Miller, M.; Runyon, M. S.; McCurdy, L. H.; Gibbs, M. A.; Ahmed, A.; Lagarde, W. H.; Maguire, P. D.; King-Thiele, R.; Hamrick, T.; Ihmeidan, A.; Henderson, S.; Gallaher, T. R.; Uschner, D.; Edelstein, S. L.; Herrington, D. M.; Sanders, J. W.; North Carolina sites of the, Covid-Community Research Partnership
PLoS One | 2022

This longitudinal North Carolina study used repeated at-home serology and symptom reporting to estimate accumulated SARS-CoV-2 infection and vaccine response. Seropositivity exceeded documented case counts and rose sharply after vaccination began, especially among healthcare workers.

SARS-CoV-2 seroprevalence among healthcare workers

Wiggen, T. D.; Bohn, B.; Ulrich, A. K.; Stovitz, S. D.; Strickland, A. J.; Naumchik, B. M.; Walsh, S.; Smith, S.; Baumgartner, B.; Kline, S.; Yendell, S.; Hedberg, C.; Beebe, T. J.; Demmer, R. T.
PLoS One | 2022

Researchers measured SARS-CoV-2 antibodies in healthcare workers before and during early vaccination. Seroprevalence rose with community infection and vaccination, while workplace role and ICU duties were associated with higher infection risk.

Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study

Neupane, B.; Pandya, H.; Pandya, T.; Austin, R.; Spooner, N.; Rudge, J.; Mulla, H.
Pharmacol Res Perspect | 2022

This prospective study modeled midazolam pharmacokinetics in critically ill and control pediatric patients. Acute inflammation, cardiovascular impairment, and weight significantly affected clearance, with simulations indicating a substantial overdose risk under current dosing in some critically ill children.

A Volumetric Absorptive Microsampling UPLC-MS/MS Method for Simultaneous Quantification of Tacrolimus, Mycophenolic Acid and Creatinine in Whole Blood of Renal Transplant Recipients

Wang, X.; Dai, X.; Wan, S.; Fan, Y.; Wu, L.; Xu, H.; Yan, L.; Gong, X.; Li, Y.; Luo, Y.; Bai, Y.; Li, Y.
Pharmaceutics | 2022

This study developed and clinically validated a single VAMS–UPLC-MS/MS assay for tacrolimus, mycophenolic acid, and creatinine in renal-transplant recipients. The method supported one-sample remote monitoring of both immunosuppressant exposure and kidney function and was preferred by patients over dried blood spots.

Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol

Pattaro, C.; Barbieri, G.; Foco, L.; Weichenberger, C. X.; Biasiotto, R.; De Grandi, A.; Fuchsberger, C.; Egger, C.; Amon, V. S. C.; Hicks, A. A.; Mian, M.; Mahlknecht, A.; Lombardo, S.; Meier, H.; Weiss, H.; Rainer, R.; Dejaco, C.; Weiss, G.; Lavezzo, E.; Crisanti, A.; Pizzato, M.; Domingues, F. S.; Mascalzoni, D.; Gogele, M.; Melotti, R.; Pramstaller, P. P.
Pathog Glob Health | 2022

This protocol describes a population-based longitudinal study of SARS-CoV-2 infection, immunity, and long-term outcomes in a rural Italian district. Repeated questionnaires, viral testing, antibody monitoring, and existing molecular and genetic data were designed to characterize infection determinants and sequelae.

Volumetric Absorptive Microsampling (VAMS) for Targeted LC-MS/MS Determination of Tryptophan-Related Biomarkers

Protti, M.; Cirrincione, M.; Mandrioli, R.; Rudge, J.; Regazzoni, L.; Valsecchi, V.; Volpi, C.; Mercolini, L.
Molecules | 2022

Researchers developed a VAMS–LC-MS/MS method for 24 tryptophan-related metabolites and biomarkers in small murine blood samples. The assay was sensitive, precise, stable for 30 days at room temperature, and suitable for disease-mechanism and therapeutic-intervention studies.

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