Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This study used targeted DNA-methylation markers and digital droplet PCR to estimate leukocyte subsets in venous and dried blood, including samples collected with Mitra devices. The epigenetic estimates correlated well with conventional cell counts, supporting accurate leukocyte analysis from dried blood samples.
Researchers developed an Excel-based tool for designing statistical quality-control programs around patient-risk parameters. The tool calculates measures such as maximum expected unreliable results and run size, helping laboratories assess current strategies and select controls that reduce patient risk.
This study evaluated whether machine learning could reduce false-positive referrals in the Dutch newborn screening program for congenital hypothyroidism. A random-forest approach showed potential to improve the program’s positive predictive value while retaining detection of the cases identified by the existing algorithm.
This study assessed whether routine blood-test results could support earlier recognition of multiple myeloma in primary care. Calculated globulin was the most promising marker and can be derived without adding a new test or cost.
This study developed and validated a VAMS dried-blood method for phenylalanine monitoring in people with phenylketonuria. Results closely agreed with plasma measurements, supporting at-home collection for clinical monitoring.
This study compared four quantitative SARS-CoV-2 antibody assays across infection, vaccination, cancer, and immunosuppressed cohorts. Quantitative and qualitative agreement was poor, showing that results from the evaluated platforms are not directly interchangeable.
This study characterized MHV370, an oral inhibitor of Toll-like receptors 7 and 8, in preclinical lupus models. The compound suppressed disease-relevant immune responses and supported advancement to phase 2 clinical evaluation.
This study validated a rapid electrochemical point-of-care assay for paracetamol in finger-prick whole blood. The method showed promise for rapid testing, although upward bias and occasional sensor performance issues require further refinement.
This narrative review examines microsampling technologies for therapeutic drug monitoring across blood and other biological fluids. It highlights how high-sensitivity LC-MS/MS can enable accurate analysis from small samples and support routine clinical implementation.
This study implemented 10 µL Mitra microsampling for pharmacokinetic assessment of baricitinib in two global pediatric trials. Concordance and repeat-analysis results were acceptable, and clinical sites reported that microsampling supported pediatric enrollment.
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