Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This pediatric study compared VAMS and dried plasma spots with fresh plasma for therapeutic monitoring of three antifungal triazoles. Concentrations correlated significantly across matrices and remained stable for at least 14 days at room temperature, supporting remote low-volume monitoring.
Researchers developed and validated a VAMS–UHPLC-MS method for therapeutic monitoring of cariprazine in psychiatric patients. Patient results agreed with standard plasma analysis, supporting VAMS as a practical minimally invasive alternative for clinical monitoring programs.
This study developed and validated a VAMS–LC-MS/MS method for imatinib and its metabolite and applied it to home-collected samples from patients with chronic myeloid leukemia. The method was suitable for routine therapeutic monitoring and demonstrated the feasibility of patient collection outside the clinic.
Researchers developed and validated manual and fully automated LC-MS/MS workflows for tacrolimus in volumetric dried blood spots. Clinical concentrations correlated well with whole blood, supporting faster and more accessible therapeutic monitoring.
Researchers developed and validated an HPLC-DAD method for measuring favipiravir in whole blood collected with VAMS. The assay met FDA bioanalytical criteria and achieved a 0.5 µg/mL lower limit of quantification.
This preclinical study compared estetrol exposure in women and mice to identify dosing conditions that better model human treatment. Continuous delivery in mice reproduced the human exposure profile more closely than simple allometric scaling, highlighting the need for carefully matched dose and route selection.
Researchers developed and validated a UHPLC-MS/MS method for simultaneously measuring favipiravir and remdesivir in VAMS samples. The assay met FDA and EMA bioanalytical requirements across clinically relevant calibration ranges.
This study characterized padsevonil pharmacokinetics and safety in healthy Chinese participants while comparing VAMS with plasma sampling. The drug was well tolerated, and the correlation between matrices suggests that VAMS may support monitoring in future antiepileptic-drug development.
This study compared self-collected VAMS whole-blood measurements of PFAS exposure with conventional venous serum testing. Results followed expected matrix differences and supported VAMS as a useful remote collection tool for identifying elevated PFAS exposure.
This study measured the stability of 31 inflammatory markers in VAMS samples stored under common laboratory conditions. Refrigerated or frozen storage preserved substantially more cytokines than room-temperature storage, emphasizing the need for analyte-specific stability planning in longitudinal studies.
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