Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Researchers developed a Mitra VAMS–high-resolution-mass-spectrometry workflow for broad toxicology screening. The method identified 87 of 90 spiked drugs and detected 98% of the compounds found in patient plasma, supporting pediatric, forensic, and mass-screening applications.
This methods chapter describes proteomic analysis of whole blood collected with VAMS for biomarker discovery. Washing the VAMS matrix can reduce abundant blood-cell proteins before digestion and LC-MS, enabling deeper coverage than conventional plasma proteomics.
Researchers compared the metabolome of VAMS capillary blood with venous blood and plasma and evaluated short-term sample stability. Capillary VAMS provided broad metabolite coverage but required freezing within six hours to prevent meaningful room-temperature changes.
This review evaluates VAMS for measuring endogenous metabolites and biomarkers across sample treatment and analytical validation workflows. Published studies generally support VAMS as a reliable, convenient collection method that can improve ambient stability for biologically important analytes.
Researchers compared Mitra VAMS finger-prick measurements of tacrolimus and creatinine with venous blood in adult kidney-transplant recipients. After correction for systematic differences, both measures met predefined prediction limits, supporting more frequent and less invasive monitoring.
This protocol describes bead-based digestion, peptide affinity capture, and LC-MS/MS measurement of low-abundance proteins from dried blood and serum samples, including VAMS. In a small-cell-lung-cancer biomarker application, VAMS produced higher signal intensities than dried serum spots and supported a transferable laboratory workflow.
This retrospective analysis examined whether prenatal sildenafil changed fetal or placental gene-expression programs in pregnancies affected by severe fetal-growth restriction. Sildenafil did not alter fetal cardiovascular or renal programming but changed several placental immune and nitric-oxide-related gene sets.
Researchers developed and independently validated an 18-small-RNA blood signature for detecting smoking-associated lung cancer. The model showed stage-dependent diagnostic performance, and dried-blood experiments suggested that the approach may eventually support home sampling.
This study developed and validated a VAMS–LC-MS/MS method for measuring vincristine in whole blood from pediatric oncology patients. The assay successfully quantified clinical samples, while the relationship between whole-blood and plasma concentrations was described by a saturable binding model.
Researchers developed and validated a Mitra VAMS–UHPLC-HRMS assay for measuring vitamin D metabolites in capillary blood collected by untrained individuals. The method was accurate, precise, and sensitive enough to identify deficiency, supporting convenient regular monitoring outside the clinic.
Microsampling and Microbiopsy specialists are available to provide expert support for the success of your project.
