Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This systematic review assessed clinical and analytical evidence for using VAMS to monitor tacrolimus and mycophenolic acid after solid-organ transplantation. Existing methods generally met agreement requirements, but correction factors and further optimization were often necessary before broader clinical implementation.
This systematic review summarizes VAMS bioanalytical design, extraction optimization, method validation, pharmacokinetic applications, and clinical use. It concludes that VAMS is promising for low-volume sampling in special populations but that each assay requires clinical validation before routine implementation.
This review outlines the HIPPOCRATES multi-partner research program for improving diagnosis, monitoring, and treatment of psoriatic arthritis. The program integrates clinical, molecular, industry, and patient expertise to address major unmet needs and improve long-term outcomes.
This study developed enantioselective chromatography–mass-spectrometry methods for several psychoactive substances and applied them to 10 µL VAMS whole-blood samples. The proof-of-concept workflow achieved useful chiral separation along with accurate and precise volumetric collection.
Researchers used dried-blood metabolomics to define signatures of aerobic and anaerobic exertion in elite professional cyclists under laboratory and World Tour race conditions. Metabolic patterns differed by exercise mode, and markers of fatty-acid oxidation correlated with competitive performance.
Researchers developed and cross-validated LC-MS/MS methods for mycophenolic acid in plasma, whole blood, and VAMS samples from pediatric renal-transplant recipients. A regression-based conversion from VAMS to plasma concentrations was successfully validated on an independent sample group.
This study developed and validated a VAMS–LC-MS/MS method for measuring perampanel in saliva from patients with epilepsy. The assay performed reliably under several storage conditions and may support simple at-home therapeutic monitoring.
Researchers developed and clinically validated VAMS–LC-MS/MS measurement of tacrolimus in pediatric renal-transplant recipients. Capillary VAMS correlated well with established methods and showed no significant clinical deviation, supporting less invasive monitoring.
This feasibility study combined weekly at-home tacrolimus microsampling with a medication-management app for adolescent and young adult transplant recipients. Most samples were collected correctly and participants reported improved dose timing, although long-term concentration variability did not significantly change.
This literature review assesses analytical and clinical validation of VAMS drug assays across different blood matrices. Many assays have been analytically validated, but clinical evidence remains limited beyond tacrolimus and mycophenolic acid, underscoring the need for broader comparison studies.
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