Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This presentation examines proposed best practices for optimizing the number of animals in toxicology studies. Each of these approaches will be discussed further to highlight the pros and cons of each in order to allow for a more informed decision when designing toxicity studies.
This preclinical presentation describes an mRNA therapy designed to produce human phenylalanine hydroxylase in a mouse model of phenylketonuria. Treatment lowered circulating phenylalanine and supported further development for patients with limited therapeutic options.
This presentation examines extraction efficiency for therapeutic drugs collected with Mitra microsampling devices. It focuses on analyte-dependent recovery and strategies for addressing extraction-related hematocrit effects.
This study applies mitra microsampling for the quantitative bioanalysis of antisense oligonucleotides. The application of Mitra VAMS to the quantification of ASOs from micro samples would greatly facilitate convenient and accurate remote sampling in support of decentralized clinical trials and patient-centric drug development.
This study examines volumetric absorptive microsampling technique in the LC-MS determination of direct oral anticoagulants. Although routine therapy monitoring is not required, there is an increasing evidence that plasma levels may vary between individuals, suggesting the benefit of plasma levels measurement in some situations.
This study validates low-volume sampling devices for pharmacokinetic analysis: technical and logistical challenges and solutions. The data generated demonstrate that the concentrations of crenezumab and etrolizumab in dried blood collected by either device could be determined using calibrators prepared in serum.
This study examines phosphatidylethanol (PEth) in practice, with a focus on a specific and proportional marker of alcohol consumption. We report the results of a quantification of palmitoyl-2-oleoyl-glycero-3-phosphoethanol (PEth 16:0/18:1) in comparison with biological indicators (SGOT, SGPT GGT) on a group of volunteers followed as outpatients for alcohol problems.
This presentation reports use of Mitra VAMS fingertip samples to measure venetoclax concentrations in a multicenter acute myeloid leukemia trial. The capillary method was found reliable and feasible for pharmacokinetic sampling across participating centers.
This study examines microsampling tools for collecting, processing, and storing blood at the point-of-care. In this review, we highlight technologies designed for patient-centric microsampling blood at the point-of-care and discuss their utility for quantitative sampling as a function of collection material and technique.
This study examines hematocrit determination using a volumetric absorptive microsampling technique in patients with pancreatic cancer. Deming regression for HctVAMS and HctVP line demonstrated very small proportional and constant biases of 1.04 and −0.003, respectively.
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