Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
Researchers optimized VAMS–LC-MS/MS measurement of doxorubicin and its cardiotoxic metabolite doxorubicinol in breast-cancer patients. The clinical samples covered the intended concentration ranges and were used to estimate that surveyed patients had a low cumulative-dose-related cardiomyopathy risk.
Researchers combined frequent 10 µL blood microsampling with wearable-sensor data to profile thousands of metabolites, lipids, cytokines, and proteins. Dense longitudinal sampling revealed individualized dietary, inflammatory, metabolic, and daily physiological patterns that may support dynamic health profiling.
Researchers combined VAMS blood collection, portable mid-infrared spectroscopy, and chemometric modeling to distinguish fibromyalgia from other rheumatologic conditions. The classification achieved 84% accuracy and identified spectral regions that may serve as point-of-care biomarkers.
This study developed and validated a Mitra VAMS–LC-HRMS/MS method for steroids and thyroid hormones relevant to relative energy deficiency in sport. Self-collected samples from active adults were measurable across the target range, supporting regular hormone assessment and recovery monitoring.
This clinical study evaluated nurse-collected and patient self-collected VAMS for therapeutic monitoring of antiseizure medications in people with epilepsy. Self-collected VAMS agreed well with plasma measurements for most drugs studied, supporting feasible at-home monitoring while identifying several medications with systematic differences.
Researchers developed a high-resolution parallel-reaction-monitoring assay for tacrolimus in VAMS samples collected at home by pediatric heart-transplant patients. Results agreed with venous blood, remained stable during shipping, and demonstrated convenient, reproducible home monitoring.
This perspective reviews how microsampling and patient-centric collection can improve drug development and clinical research. It discusses analytical and operational challenges, bridging requirements, regulatory needs, sustainability, privacy, and future technology integration.
Researchers developed and validated a VAMS LC-MS/MS method for lurasidone and compared dried-blood results with plasma. The two approaches agreed in proof-of-concept testing, supporting microsampling as a lower-waste strategy that can reduce animal and sample burdens.
Researchers developed patient-centric microsampling methods for measuring urine albumin-to-creatinine ratio in clinical studies. Both approaches showed excellent accuracy and precision compared with standard laboratory analysis, supporting at-home monitoring in kidney-drug development.
Researchers compared serum, dried serum spots, and VAMS for therapeutic monitoring of ganciclovir. The validated LC-MS/MS assays were statistically interchangeable, while the dried formats offered easier collection, storage, transport, and shipment.
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