Dive into our dynamic, ever-growing library of peer-reviewed publications, posters, application notes, and presentations showcasing the full breadth and depth of Trajan microsampling technologies. Discover cutting-edge methods, compelling scientific breakthroughs, and real-world applications spanning a wide range of disciplines.
This study developed and cross-validated an LC-MS/MS method for PEth using three dried-blood sampling systems. Samples from the devices could be prepared and analyzed with a common procedure, supporting calibration transferability across formats.
This review presents seven pharmaceutical case studies of patient-centric sampling in clinical development. The examples highlight benefits for remote collection, recruitment, diversity, comfort, and efficiency while outlining practical implementation challenges.
This study compared VAMS capillary sampling with venous plasma for monitoring common antibiotics used in periodontal treatment. Although concentrations differed by matrix, VAMS reflected concentration trends and was considered acceptable for PK and monitoring applications.
This study evaluated VAMS for simultaneous cadmium and lead biomonitoring in human blood. Results showed strong correlations with venous blood and demonstrated that pre-washing VAMS devices can reduce background contamination, especially for lead.
This study compared dried blood microsampling methods for oxylipin analysis in newborn blood using UPLC-MS/MS. VAMS and pre-cut DBS showed promise for low-volume clinical analysis, with stability and storage conditions identified as important considerations.
This feasibility trial assessed whether participants could accurately self-collect microsamples and related safety data at home during a Phase 1 PK study. Results supported the feasibility of remote blood microsampling, ECG, and vital-sign collection.
This study developed and cross-validated VAMS and a comparator device-B workflows for monitoring adherence to cardiovascular drugs. The findings support capillary microsampling as a practical approach for decentralized adherence monitoring, while noting analyte-specific stability considerations.
This biomonitoring study compared DBS, Mitra VAMS, and hemaPEN for PFAS measurement during at-home sampling and ambient postage. Mitra showed strong stability and robustness, supporting its use in large-scale PFAS biomonitoring.
This study compared metabolite profiles across plasma, serum, whole blood, and dried blood collected using Mitra devices. The work highlights how matrix and collection method affect metabolomic interpretation and supports careful matrix selection in microsampling studies.
This validation study developed an LC-MS/MS method for measuring cefazolin in VAMS whole blood, plasma, and plasma ultrafiltrate. The method showed robust analytical performance and potential for pediatric therapeutic drug monitoring and PK/PD studies.
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