Microsampling Capillary Blood | Advantages, Challenges

Remote & Decentralized Sampling:

This method allows for blood collection at home or in remote locations without the need for specialized medical staff, potentially improving participant compliance and retention.

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Minimally Invasive & Patient-Friendly:

Microsampling requires only small-volume blood collection through methods like finger-sticks or heel-sticks, which can reduce patient anxiety and discomfort. This feature may enhance participant adherence, especially in pediatric or long-term studies.

Efficient & Cost-Effective Collection:

Compared to conventional blood sampling methods, microsampling typically involves minimal preparation, storage, and transportation logistics, which can lower overall project costs.

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Ethically Conscious Research:

The reduced blood volume required for microsampling can significantly minimize health risks and enhance ethical compliance, making it especially valuable in pediatric studies, research involving vulnerable populations, and animal studies.

Hematocrit, which refers to the proportion of blood made up of red blood cells, can significantly affect the accuracy of traditional dried blood spot (DBS) methods. Variations in hematocrit levels, whether higher or lower, can result in inconsistent outcomes, complicating the interpretation of important biomarkers.

Recent advancements in blood microsampling technology aim to address these hematocrit-related issues, offering more accurate and reproducible results across a range of hematocrit levels.

Volumetric Precision:

VAMS enables accurate volume collection regardless of blood viscosity or hematocrit levels, leading to improved reliability in sample collection.

Reliable Analysis:

Samples gathered through VAMS can provide consistent and accurate analytical data, making them suitable for clinical diagnostics and therapeutic drug monitoring.

Simplified Workflow:

The sample collection and preparation processes are streamlined with VAMS, which may help reduce variability caused by user technique or environmental factors.

Enhanced Stability:

Blood samples collected using VAMS are stored and transported as dried samples, eliminating the need for refrigeration or special handling.

Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria	Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development
Using Mitra sampling to support first-in-human pharmacokinetic evaluations for PF-07059013	Microsampling in pediatric studies: pharmacokinetic sampling for baricitinib (Olumiant™) in global pediatric studies

Investigating biological mechanisms of adverse birth outcomes and early child development in Amhara, Ethiopia: protocol of biospecimen collection and analysis of the Enhancing Nutrition and Antenatal Infection Treatment (ENAT) randomised effectiveness study	Blood lead levels in children 5–7–years from the Republic of Georgia—a feasibility study on lead surveillance using volumetric absorptive microsampling
Undiagnosed COVID-19 in households with a child with mitochondrial disease	Infliximab Level Between Venous and Capillary Blood Using Novel Device Strongly Correlate in Paediatric Inflammatory Bowel Disease Patients

Tacrolimus can be reliably measured with volumetric absorptive capillary microsampling throughout the dose interval in renal transplant recipients	Development and application of an LC-MS/MS method for 8 antiepileptic drugs and 2 metabolites using microsampling techniques (DBS and VAMS)
Therapeutic drug monitoring of mycophenolic acid (MPA) using volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients: ultra-high-performance liquid chromatography-tandem mass spectrometry analytical method development, cross-validation, and clinical application	Dried Volumetric Microsampling Approaches for the Therapeutic Drug Monitoring of Psychiatric Patients Undergoing Clozapine Treatment

Self-Collection Blood Test for PFASs: Comparing Volumetric Microsamplers with a Traditional Serum Approach	Mercury biomonitoring in German adults using volumetric absorptive microsampling
Volumetric Absorptive Microsampling as an Alternative Tool for Biomonitoring of Multi-Mycotoxin Exposure in Resource-Limited Areas	Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States

Volumetric absorptive microsampling to measure iohexol and creatinine concentrations for estimation of glomerular filtration rate in cats: aligning animal welfare with practical feasibility	Quantification of vincristine and tariquidar by liquid chromatography-tandem mass spectrometry in mouse whole blood using volumetric absorptive microsampling for pharmacokinetic applications
Use of Mitra® to test mice for novel MOG analogues showing improved stability to explore the biology of 2 MCT2 and α-ketoglutarate.	Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

DBS Technology: Microsampling Capillary Blood

Remote & Decentralized Sampling:

Minimally Invasive & Patient-Friendly:

Efficient & Cost-Effective Collection:

Ethically Conscious Research:

Understanding Hematocrit: A Key Challenge in Microsampling

How VAMS® Technology Can Address the Hematocrit Challenge

Volumetric Precision:

Reliable Analysis:

Simplified Workflow:

Enhanced Stability:

VAMS Across Industries: Reliable, Compliant, and Proven.

Clinical Trials

Pediatrics & Neonatology

Therapeutic Drug Monitoring (TDM)

Population Health Studies

Veterinary & Preclinical Research

Explore Microsampling for Your Research