Storing and shipping whole blood samples poses significant challenges and costs.
After collection, whole blood samples must be tested immediately or stored and transported under strict temperature and environmental conditions for analysis or other applications. Characteristics of whole blood samples begin to change within hours of collection if they are not refrigerated or frozen.
Maintaining the stability of liquid whole blood samples is essential. Since blood components begin to degrade immediately, extended exposure to ambient temperatures dramatically affects the outcome of any analysis. Therefore, medical organizations around the world have created guidelines for the proper storage, packaging, and shipping of whole blood samples.
For example, the Food and Drug Administration (FDA) in the United States recommends that liquid whole blood samples that are held in specialized containers (i.e., tubes) should only be kept in a refrigerated state for 42 days. However, it is recognized that some changes in the samples may occur during that time.
Another government agency, The National Institute of Health and Welfare in Finland, determined that whole blood samples, refrigerated at 4°C (or about 39°F), should only be held for up to seven days before discarding.
When liquid blood samples must be shipped to another location by air or ground, the packaging, labeling, and handling instructions are very stringent. Since liquid blood samples are considered bio-hazardous materials, samples must be packed with several layers of protection and kept cold with dry ice or other refrigeration methods. Containers must be clearly marked for special handling.
International shipments require far more documentation and must comply with local regulations, which may differ from country to country.
An efficient and far less complicated solution is to use dried blood sampling instead of liquid blood sampling. With a dried blood spot (DBS) method, capillary blood samples can be drawn by pricking a fingertip or the arm to collect a few drops of blood onto a small DBS card or onto a volumetric microsampling device.
A microsample of capillary blood can be air dried at room temperature on a DBS card. Blood microsamples collected on the Mitra or hemaPEN device are ready for immediate transport – they will dry in transit. The dried blood samples retain their integrity through the entire process of shipping and storing at ambient temperatures until the samples are ready to be analyzed in the lab.
Dried blood microsampling brings efficiency to the blood sampling process by reducing time and simplifying shipping and handling. Organizations that transition from liquid blood sampling to dried blood microsampling are able to reduce costs associated with blood sample collection and the entire sample workflow.
Here are some advantages of using dried blood sampling over whole blood sampling procedures:
Learn how to apply dried blood microsampling in your industry:
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