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General Questions

What is microsampling?

Advances in bioanalysis now allow for the assessment of drug and chemical exposure from smaller specimen samples. With Volumetric Absorptive Microsampling (VAMS™) technology, dependable data can be obtained from specimens as small as 10 and 20 µL.  

What is the Mitra microsampler?

The Mitra microsampler is a non-invasive biological fluid collection device that allows users to run clinical or research tests from a single drop of blood.  It also enables remote specimen collection with minimal training which yields high-quality data from 10 or 20 µL of fluid.

What fluids is it compatible with?

Mitra microsampling technology is compatible with almost any fluid. Common matrices include: whole blood, plasma / serum, urine, saliva, CSF, and tears. Less common matrices include: wound exudates, cervical fluid, ocular fluid, and more.


Is the device sterile?

The Mitra microsampler is not sold as a sterile product. However, the product is extremely clean and manufactured in a GMP environment. Gamma sterilization tests have been successful, and our customers can use this process if they choose.

What industries use Mitra microsampling technology?

Mitra microsampling technology can be used in any industry in which biological fluid samples are tested. This includes animal and human (academia) research, pharmaceutical development, clinical diagnostics and healthcare settings. We are researching new applications and would love to discuss potential new uses for the technology - contact us to share your ideas, and you may qualify for a complimentary evaluation kit.

What formats are available, and how do they differ?

The Mitra microsampler is available in a variety of formats suited to different use cases. These include the Clamshell format, the Cartridge format, the 96-rack and 96-autorack, and a Collection Convenience Kit designed for easy at-home sampling. Compare our products with this chart to see which items best fit your needs.

Is the Mitra microsampler an FDA listed medical device?

Yes, the Mitra microsampler is registered at the U.S. Food and Drug Administration (FDA) as a Class 1 Medical Device.  The device is also registered as CE / IVD. 

What test panels is Mitra microsampling technology compatible with?

Users of the Mitra technology have proven compatibility with a wide menu of panels including therapeutic drug monitoring / medication adherence of a variety of pharmaceutical drugs, HbA1c, vitamin D, illicit drugs, micronutrients, metals, poisons, DNA / RNA, etc. Download the VAMS publication list or visit our Resource Library to learn more. 

What is the difference between Mitra microsampling technology and Dried Blood Spot (DBS) cards?

The Mitra device has advantages over DBS cards and filter paper in the areas of collection, processing, and extraction. The Mitra device provides the key benefits of working with dried blood, but with a volumetrically accurate, stable dried blood sample that reduces the incidence of reworks. 

Analyte Compatibility

What can I extract from only 10, 20 microliters?

Around fifty references prove that a wide range of analytes can be extracted from the Mitra® microsampler, including small and large drug molecules, nucleic acids, metals, and more. A current list is available here.

I didn’t see my analyte on the list? Now what?

As our technology adapts to meet new and growing needs, our researchers and customers are constantly experimenting with new analytes. If you have questions about an analyte we don’t currently mention, contact your Microsampling Specialist and let us know.


How much does it cost?

The cost of Mitra microsampling technology varies depending on the needs and implementation requirements of the client. Your microsampling specialist will help you determine your best value.

Where can I purchase a Mitra microsampler?

Mitra microsampling products can be purchased directly from Neoteryx or from one of our authorized distributors.

How exactly does switching to microsampling save money?

Initial implementation requires an upfront investment and may disrupt existing workflow, depending on the current processes in place. However, any initial friction is well worth it - Mitra microsampling technology saves money  (e.g. no cold-chain shipping), labor (e.g. compatible with typical liquid handling instrumentation), and resources (e.g use non-clinical staff to collect specimens) over time while better allowing for future growth.

Do you sell and ship internationally?

We do sell and ship internationally. Shipping outside the United States may incur VAT and other added costs. Contact a microsampling specialist to learn more.

What currencies do you accept?

We currently accept: USD, EUR, GBP, and CAD. If you prefer to pay in a currency not listed, please contact a microsampling specialist to discuss this option. 



Is Mitra automatable?

Mitra automation solutions are available that allow medium- and high-throughput labs to process hundreds or thousands of samples per day. Contact your Microsampling Specialist to learn more.

What if I don’t have a liquid handler?

All Mitra formats can be processed manually. The tips can be picked up by hand, or with most common p20/200 pipettes, and extracted in a standard tube or collection plate. No special equipment, instruments, or reagents are required.

Medical Home Care / Patient Centered Care

What is patient-centered care?

Defined by the Institute of Medicine as the act of "providing care that is respectful of, and responsive to, individual patient preferences, needs and values, and ensuring that patient values guide all clinical decisions," patient-centered care prizes transparency, compassion, and empowerment. It represents a paradigm shift in how patients, providers, and other participants think about the processes of treatment and healing.

How does microsampling fit into this model of care?

Advances in remote sampling technology allow blood collection outside the clinic. In therapeutic drug monitoring and other challenging situations that require regular biological specimen collection, remote sampling using Mitra® devices can make things much easier, facilitating a more pleasant patient experience, eliminating stressful and unnecessary travel and time commitments, and keeping patients happy and together with their families and communities.

Sample Preservation

How long can I keep a blood sample on a Mitra?

The maximum storage time will depend entirely on the analyte of interest and storage conditions. Samples can typically be stored longer in the refrigerator or freezer, in a sealed bag with desiccant. Stability tests should be performed at each of these temperatures before collecting any samples to ensure proper guidelines are established beforehand. Speak with your Microsampling Specialist for the most accurate and up-to-date information.

How should I store Mitra when sampling outside the clinic?

All storage recommendations should follow the specific assay’s stability data as it was validated by the laboratory performing the analysis. Most samples can be stored and shipped at room temperature, while some must be placed in a refrigerator or freezer as soon as they dry. Your Microsampling Specialist can offer specialized guidance if needed.

Preclinical Applications / Animal Testing

Can Mitra microsampler be used in preclinical trials and animal testing?

Animal sampling in preclinical contexts is among the most popular applications for this technology. Mitra microsampling allows preclinical studies to break free of the familiar "one mouse, one time point" design.  It reduces (by up to sevenfold) the number of animals required for pharmacokinetic, toxicokinetic, pharmacodynamics, and efficacy studies, with reduced costs and improved data quality. It also reduces animal stress and reliance on satellite populations, along with many other advantages.

Is it true that serial sampling with Mitra microsampler can reduce inter animal variability?

Yes. Traditional, or composite sampling, relies on using one individual mouse per data point, then pooling the data together to determine an overall trend. Although the dosing, animal weight, etc. are standardized, there may still be unknown metabolic differences that contribute to variance in the data (inter-animal variability). With Mitra and other serial sampling techniques, this same data is taken from one individual animal, and therefore inter-animal variability is eliminated.

How can Mitra microsampling aid in upholding the NC3Rs?

Serial sampling reduces the overall number of animals used without sacrificing data quality. It reduces animal stress and facilitates a more refined workflow, ideal for labs that plan to cut costs or streamline processes for future growth.


Clinical Research

Is there a correlation between venous and capillary blood?

Our customers have produced bridging data showing correlations between venous blood draws and fingerstick blood draws, but there is a dependence on the analytical workflow and the compounds to be analyzed. Different analytes are known to circulate differently in venous and capillary blood, so studies will need to be done for each individual analyte and assay.

Can the Mitra microsampler be use for at home or remote sampling?

Yes. At-home or remote sampling with the Mitra microsampler is quick and convenient and requires minimal training. Watch this video to see how it works.

Why is microsampling so popular with therapeutic drug monitoring (TDM)?

The use of dried microsamples has produced strong correlations to the "gold standard" analytical methods for drug concentration determination. The advantages in participant comfort and ease of use make it an obvious choice for therapeutic drug monitoring.

What is the cost of using Mitra microsampling technology in clinical trials?

Clinical trials include so many variables that making blind estimates is impossible. Our Clinical Cost Calculator tool will help you determine how much you can save by switching from wet blood to Mitra microsampling technology. Contact us to learn more.


Why is capillary blood sampling a better alternative for pediatrics?

Microsampling procedures eliminate the pain of venipuncture and the stress of unnecessary visits to the clinic. Microsampling helps provide a more comfortable and pleasant experience for children. It has applications in pediatric therapeutic drug monitoring (TDM) as well PK/PD studies.

What are the benefits of needleless blood collection?

Traditional venipuncture using needles is scary and stressful for children, who experience pain differently from adults and may not be able to understand what’s going on. Needleless blood collection using microsampling technology creates a better experience for young patients and participants, which can benefit them for the rest of their lives.

Molecular Genetics (DNA/RNA)

Can the Mitra microsampler be used with molecular tests?

Yes, Mitra microsampling technology allows scientists to yield NGS-grade DNA/RNA from dried blood collected in the clinic or remotely.

Is it possible to extract DNA/RNA from the Mitra microsampler?

Yes, it is possible to extract 450 ng DNA per 20 µL Tip or 100 ng RNA per 20 µL tip. We recommend using Norgen Biotek RNA/DNA extraction kits available through Neoteryx.

What is the stability of DNA/RNA on the Mitra microsampler?

DNA/RNA on a Mitra microsampler tip has been shown to remain stable for at least seven days.

Can the Mitra microsampler be used with next generation sequencing?

In this study, both total RNA (large mRNA and microRNA) as well as total DNA were shown to be preserved in the tip when dried on the Mitra device. The isolated DNA and RNA can be used in downstream molecular tests including qPCR, RT-PCR, sequencing, SNP analysis, and next generation sequencing.

Can the Mitra microsampler be used to detect infectious diseases?

Although Neoteryx itself does not perform such tests, we have clients testing for both disease antibodies, as well as bacterial or viral RNA/DNA for the detection of infectious diseases.