R&D poster presented at American Pediatrics Association (APA) conference 14-15 April, Liverpool

midazolam measurement and modelling using matrix samplers



The Mitra Microsampler class I medical device is for direct specimen collection of blood and other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Microsampler in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA requirements.

This poster includes prelimary data showing midazolam concentrations in wet blood and volumetric absorptive microsampling (VAMS) samples were closely correlated with no systemic bias for PK values in critically ill versus clinically well children undergoing elective surgery administered IV drug. 


Highlights of this research include: 

  • Over 300-fold difference in blood midazolam concentrations and a 30-fold difference in blood 1-OH midazolam concentrations in children receiving IV drug 
  • Correlation coefficients between concentration of midazolam and 1‐OH midazolam obtained via wet and VAMS
    dried blood were respectively 0.97 and 0.97 with a bias of 3.5 %