Mitra® microsampling technology is used to collect 10 and 20 µL of a variety of biological fluids.  If you believe that microsampling could be a novel sampling solution for your purpose - please contact us. You may qualify for a complimentary evaluation kit.

Resource Bundles

A collage of case studies discussing Pediatrics research and specimen collection with Mitra Microsampler

Pediatric Applications | Microsampling Children  

This bundle includes essential information on collecting small volume specimens from children and detailed pediatric case studies. Download

Pediatrics Research | Clinical Trials | Patient Perspective

collage of various case studies involving therapeutic drug monitoring and Microsampling

Microsampling Applications in Therapeutic Drug Monitoring (TDM)

This bundle illustrates how dried blood microsampling facilitates medication adherence and enables collections outside the clinic. Download

Antibiotics | Antipsychotics | Immunosuppressants
collage of case studies examining the similarities between capillary blood to whole blood plasma in Clinical Research

Capillary vs. Venous Blood and Wet vs. Dry Specimens

This bundle presents data comparing outcomes of drawing blood from a vein or fingerstick in both dried and wet forms. Download

Comparative Data | Case Studies | DBS Card Alternative
click this image collage to visit our third party case studies that utilize a Micro specimen collection protocol

Preclinical Applications | Microsampling Animals

This bundle illustrates how dried blood microsampling can reduce animal use by sevenfold and facilitate consistent, quantitative sample collection. Download

Benefits of Microsampling Animals | Achieving The 3R's 

Clinical Research & Microsampling | Method Applications

This bundle explores microsampling in a clinical context. Find out what 10-20 µL can do for you, your donors, and your lab. Download

Evaluation Case Studies | Downstream Compatibility
Discover the advantages of using Mitra over traditional dried blood spot cards.  Mitra offers the first volumetric reliable Microsampling collection method

Dried Blood Spot Vs Mitra Volumetric Absorptive Microsampling

Compared to results generated from filter paper, results from Mitra microsamples are closer to the "gold standard" assocated with wet blood. Download

Comparative Studies of DBS Cards & Mitra Microsampler 

Application Notes

In Vivo PK study demonstrating the data similarities of using microsampling versus traditional sample collection

Conventional vs. Microsampling Methodologies In Vivo PK studies

Advantages of using the VAMS™ method for rodents against traditional wet blood collection for PK and PD studies. Download

In Vivo PK Studies | Experimental Animals  

Application note demonstrating the successful extraction of NGS grade DNA RNA from Dried Blood Microsamples

RNA / DNA Isolation and Purification From Dried Blood Microsamples (VAMS)

RNA / DNA isolation and purification from dried blood microsamples were successfully used in downstream molecular tests. Download

DNA / RNA Purification | Next Generation Sequencing

application note of a clinical case study evaluating the Mitra Microsampler for Immunosuppressants Monitoring

Evaluation of the Mitra Microsampler for Immunosuppressants Monitoring

At-home microsampling provides transplant recipients an option for self-collecting and sending samples to the clinic. Download

TDM Using Dried Blood | Immunosuppressants 




R&D Posters

Image of a research and development paper, evaluating Mitra microsampler in a therapeutic monitoring study tacrolimus

Development of Potential At-Home Assay for Tacrolimus Monitoring

At-home therapeutic drug monitoring for tacrolimus using microsampling can reduce costs and improve experience. Download

TDM | Tacrolimus | Wet Blood vs Capillary Blood

Research and development poster outlining the development of a microsampling technique for the therapeutic drug monitoring of IGF-1 in patients with acromegaly

Monitoring IGF-1 in Blood Using Volumetric Absorptive Microsampling

Specimen collection with a Mitra® device is compatible with downstream immunoassay analyzers.  Download

Serum / Plasma vs Whole Blood | Immunoassay 

research and development poster evaluatinf of the Mitra Microsampler For PK/PD study of Beta-lactams

Evaluation of Mitra Microsampler For PK/PD study of Beta-lactams

St. George's University of London evaluates the Mitra microsampling device for sampling accuracy and precision. Download

PK / PD | Antimicrobials

Research and development poster on the midazolam measurement and modelling using matrix samplers

Pediatric TDM of Midazolam: Plasma vs Capillary Blood (VAMS)

A 71-patient study shows preliminary data comparing blood midazolam and 1‐OH midazolam concentrations determined from wet blood samples and VAMS. Download

Pediatrics | Capillary Blood vs Plasma

Research and developoment poster of sport drug testing using Urine Microvolumes collected with a Mitra Microsampler

Sport Drug Testing Using Dried Urine Microvolumes

Simple but reliable protocols have been developed and validated for the collection of dried urine microvolumes. Download

Sports Drug Testing | Dried Urine Microvolumes

Research and development poster over therapeutic drug monitoring of Pyschotropic Synthetic Compounds Using Dried Blood (VAMS) Microsampling

TDM of Pyschotropic Synthetic Compounds Using Dried Blood (VAMS) Microsampling

This work covers the development of a novel, yet simple analytical approach using dried blood microsampling for rapid determination of new psychoactive substances .  Download

Using Dried Blood for TDM of NPSs | Legal High Drugs

Research and development poster of a Therapeutic Drug Monitoring of Atypical Antipsychotics drugs using micro samples of dried blood versus plasma

TDM | Atypical Antipsychotics | Plasma vs Capillary Blood Comparison 

In theraputic drug monitoring, microsampling methods generate comparable results to traditional analyses and offer some practical advantages. Download

TDM | Central Nervous System Drugs | Comparative Study of Sample Collection Methods

Research and development poster medication adherence haematocrit (Hct) effect

Medication Adherence Study Comparing DBS Cards Against Mitra VAMS 

Does VAMS technology offset the HCT bias associated with DBS cards? This project compares side-by-side data to quantitatively determine the levels of 11 selected cardiovascular drugs in patient samples. Download

TDM | Medication Adherence | Haematocrit (Hct) effect

Research and development scientific poster on the PK profile findings of a large molecule

Determination of a Single-Rodent PK Profile for a Large Molecule

This study demonstrates the applicability of VAMS technology for the generation of a PK-profile derived from a single rodent for exenatide. Download

Microsampling Accuracy Study | LC-MS/MS | Large Molecule

Research and Development poster evaluating Mitra Microsampler Device for use with metabolic diseases

Evaluating Mitra Microsampler For Use With Metabolic Disease Alkaptonuria

In this study, Mitra was evaluated using whole blood and urine. Sampling accuracy and imprecision were assessed gravimetrically using three sampling techniques. Download

 Wet Blood vs Urine vs VAMS | Comparion | Analysis

Webinars / Seminars

Speakers at the Dusseldorf workshop presenting their case studies

Düsseldorf Workshop | Clinical Case Studies 

See clinical research content presented at the Microsampling Workshop by leading scientists and blood microsampling experts. Download

Case Studies | Capillary Blood vs Plasma | TDM

webinar exploring specimen collection with microsampling in the clinical research industry

Webinar | Do Dried Blood Microsamples Have a Place in Clinical Research Labs?

A next-generation blood microsampling device overcomes many DBS challenges - it's being explored and validated by clinical reseach labs. Watch

Clinical Reseach Validation | Dried Blood Sampling

Webinar | microsampling for in Vivo DMPK Studies

Webinar | Advance microsampling (VAMS) for in Vivo DMPK Studies

This webinar discusses the advantages of using dried blood Mitra microsampling devices for In Vivo DMPK studies in rodents. Watch

Experimental Animals | In Vivo PK 

microsampling presentations presented at MSACL 2017 Palm Springs

Microsampling Case Studies Presented at MSACL 2016 (USA)

Review highlights from the conference along with some all-new material, with research from Mayo Clinic, Exagen Diagnostics, Cedars-Sinai Medical Center, and more. Download

TDM | Proteomics 


A landscape image of austria during the MSACL 2016 Conference

Microsampling Case Studies Presented at MSACL 2016 Austria (EU)

Review highlights from the conference along with some all-new material, including research from University of Leicester, Leeds Teaching Hospital, and more. Download

Mitra Microsampler vs DBS | Pediatrics 


bioanalysis webinar on exploring microsampling

Webinar | Exploring Microsampling 2017

Microsampling has gained increasing attention within the bioanalytical community as more sensitive bioanalytical technologies develop, allowing for simpler workflows. Watch

Preclinical and Clinical  | The Future of Specimen Collection 

Speakers at the London workshop presenting their case studies

London Workshop | Preclinical and Clinical Case Studies 

Review preclinical and clinical research content presented at the Microsampling Workshop by leading scientists and blood microsampling experts. Download

Case Studies |  Capillary Blood vs Plasma | TDM




Video demonstrting the benefits of Microsampling in 90 seconds

Benefits of Mitra Microsampling in 90 Seconds | Quantitative & Easy-to-Use

In 90 seconds, Absurd James walks you through the benefits of Mitra microsampling for specimen collection. Watch

At-Home Sampling | Reduce Transportation Costs

Taking a micro sample of blood from a rats tail

Next Generation Dried Blood Sampling Technology

Mitra microsamling delivers cost saving and convenient sampling advantages to pharma and clinical organizations. Watch

At-Home Sampling | Reduce Transportation Costs

Using a PAL RTD liquid handler to batch process dried blood microsamples

Mitra Device Extraction Automated on The PAL® RTC System

See how the microsampling is automated to empower labs with high throughput demands. Watch

Dried Blood Automation | High Throughput Lab

Using the auto-mitra desktop semi automated 96 pipetter with the mitra 96 auto rack

Semi-Automated Processing of Mitra Dried Blood Microsamples

Process hundreds to thousands of samples per day using the autoMitra™ workflow, powered by the INTEGRA VIAFLO® 96 electronic pipette. Watch

High Throughput Extraction | Dried Blood Processing

Taking a blood microsample with the purple Mitra cartridge

At-Home Blood Sample Collection With Mitra Cartridge 

At home sampling / remote blood collection, has never been simpler than with the bar-coded Mitra cartridge. This less invasive procedure improves care and promotes adherence & compliance. Watch

High Throughput Extraction | Dried Blood Processing

Taking blood microsamples with a mitra clamshell - clcik to watch the making of mitra video

The History, and Making of The Mitra Microsampler 

Advances in bioanalysis detection technology have made microsampling a reality. The Mitra Volumetric Absorptive Microsampling (VAMS™) tech, collects dependable data as small as 10-20 µL. Watch

Cost Savings Benefits of Microsampling | Easy At-Home Sampling

Brochures / Mitra Manuals

publications list of Mitra microsampler

VAMS Publication List 

A directory of case studies and research publications that have collected biological specimens with the Mitra Microsampler.  Download

VAMS Publications | Proof of Concept

Mitra Microsampling products Brochure

 Mitra Devices & Accessories Brochure

Improve profitability of operations, donor experience, increase efficiency and facilitate simpler remote sampling. Download

Mitra Formats | 10 and 20 µL Microsampler

Bioanalysis e-book cover of exploring Microsampling 2017

Bioanalysis Zone Exploring Microsampling | E-book

Microsampling has become a relevant solution, particularly in the context of the 3R's. Modern bioanalytical instruments and novel microsampling technologies, are facilitating simpler workflows. Download

The 3R's | Sports Drug Testing | Bioanalysis

image of the Mitra cartridge instructions pdf

Mitra Cartridge Instructions For Use

A step-by-step guide to collecting accurate microsamples with the cartridge format of the Mitra microsampling device. Download

IFU | Mitra Cartridge 

mitra 96 autorack instructions for use

Mitra 96-autorack Instructions For Use 

A step-by-step guide to collecting accurate microsamples with the 96-autorack format of the Mitra microsampling device. Download

IFU | Mitra 96-autorack

image of the Mitra Clamshell and 96-rack Instructions

Mitra Clamshell and 96-rack Instructions For Use 

Follow these steps to collect accurate microsamples with the clamshell format of the Mitra microsampling device. Download

IFU | Mitra Clamshell | Mitra 96-rack

Journal Manuscripts

  • Dried haematic microsamples and LC-MS/MS for the analysis of natural and synthetic cannabinoids. Read
  • Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study. Read
  • Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples. Read
  • LC-MS/MS and volumetric absorptive microsampling for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples. Read
  • Quantitative bioanalysis of paracetamol in rats using volumetric absorptive microsampling (VAMS). Read
  • Capillary Blood Collected on Volumetric Absorptive Microsampling (VAMS) Device for Monitoring Hydroxychloroquine in Rheumatoid Arthritis Patients Read
  • Determination of ultra-trace amounts of prosthesis-related metals in whole blood using volumetric absorptive micro-sampling and tandem ICP – Mass spectrometry. Read
  • Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study. Read


  • Novel procedures for analysis of dried plasma using microsampling devices to detect sulfur mustard-albumin adducts for verification of poisoning. Read 
  • Volumetric Absorptive Microsampling: A Dried Sample Collection Technique for Quantitative Bioanalysis. Read 


  • Iron isotopic analysis of finger-prick and venous blood by multi-collector inductively coupled plasma-mass spectrometry after volumetric absorptive microsampling. Read 


  • Evaluation of sample extraction methods for minimizing hematocrit effect on whole blood analysis with volumetric absorptive microsampling Read 
  • Hepcidin determination in dried blood by microfluidic LC-MS/MS: Comparison of DBS and volumetric absorptive microsampling for matrix effect and recovery Read 
  • Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling Read 
  • Evaluation of two blood microsampling approaches for drug discovery PK studies in rats Read 
  • Bioanalysis of emixustat (ACU-4429) in whole blood collected with volumetric absorptive microsampling by LC-MS/MS Read 
  • A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated with blood hematocrit Read