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Determination of a Single-Rodent PK Profile for a Large Molecule


This study demonstrates the applicability of Volumetric Absorptive Microsampling (VAMS™) technology for the generation of a PK-profile derived from a single rodent for exenatide, a 4.2 kDa GLP-1 agonist biotherapeutic used in the treatment of type 2 diabetes.

The VAMS method for exenatide demonstrated a linear range between 2.0 -1000 ng/mL with intra-assay precision and accuracy ≤ 8.8% and ≤ 2.6%, respectively.

Average recovery was 75%, obtained without hematocrit effect. Individual PK-profiles successfully derived from three subjects were in excellent agreement.